Literature DB >> 18653118

Age-related changes in plasma lipid peroxidation and antioxidant system in humans and rats.

G Mehmetçik1, G Ozdemirler, O Kanbagli, G Toker, M Uysal.   

Abstract

This study was carried out on young (20-35 years) and old (60-85 years) men and rats (6 vs 22 months) to investigate the effect of aging on plasma lipid peroxidation and the antioxidant system. Plasma polyunsaturated fatty acid (PUFA), total fatty acid (TFA) and malondialdehyde (MDA) levels increased in aged humans and rats compared with young groups. However, plasma MDA/TFA ratios did not increase in aged humans and rats. Plasma vitamin E/TFA, and total thiol content were found to decrease both in aged humans and rats. Plasma antioxidant activity (AOA) decreased only in aged rats. In addition, the susceptibility of VLDL+LDL, apolipoprotein B containing lipoproteins to copper-induced peroxidation increased with aging. It is concluded that aging is associated with some variations in plasma oxidant-antioxidant balance.

Entities:  

Year:  1997        PMID： 18653118     DOI： 10.1016/s0167-4943(97)00023-x

Source DB:  PubMed          Journal:  Arch Gerontol Geriatr        ISSN： 0167-4943            Impact factor:   3.250


  5 in total

1.  Increased susceptibility of serum and apo-B-containing lipoproteins to peroxidation in aged rats.

Authors:  B Depboylu; S Doğru-Abbasoğlu; G Aykaç-Toker; M Uysal
Journal:  Clin Exp Med       Date:  2008-01-11       Impact factor: 3.984

2.  Changes in serum levels of MDA and MMP-9 after UPF in patients with OSAS.

Authors:  Erkan Vuralkan; Murad Mutlu; Ibrahim Hikmet Firat; Sevgi Akaydin; Mustafa Sagit; Istemihan Akin; Ece Miser; Sadık Ardic
Journal:  Eur Arch Otorhinolaryngol       Date:  2013-11-19       Impact factor: 2.503

3.  Guaraná (Paullinia cupana Kunth) effects on LDL oxidation in elderly people: an in vitro and in vivo study.

Authors:  Rafael de Lima Portella; Rômulo Pillon Barcelos; Edovando José Flores da Rosa; Euler Esteves Ribeiro; Ivana Beatrice Mânica da Cruz; Leila Suleiman; Felix Alexandre Antunes Soares
Journal:  Lipids Health Dis       Date:  2013-02-08       Impact factor: 3.876

4.  Decreased IL-7 responsiveness is related to oxidative stress in HIV disease.

Authors:  Magdalina Kalinowska; Douglas A Bazdar; Michael M Lederman; Nicholas Funderburg; Scott F Sieg
Journal:  PLoS One       Date:  2013-03-07       Impact factor: 3.240

Review 5.  Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives.

Authors:  Konstantinos Archontogeorgis; Evangelia Nena; Nikolaos Papanas; Paschalis Steiropoulos
Journal:  Pulm Med       Date:  2014-11-27
  5 in total

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