| Literature DB >> 18652761 |
L D Wang1, Y H Yang, Y Liu, H T Song, L Y Zhang, P L Li.
Abstract
The aim of this study was to evaluate whether the expression of annexin A1 (ANXA1) is associated with the progression of cervical neoplasia. ANXA1 expression was examined by immunohistochemistry in paraffin-embedded cervical tissue samples (n = 234), comprising 52 samples of normal cervical epithelia, 30 of cervical intraepithelial neoplasia (CIN) I, 27 of CIN II, 32 of CIN III, and 93 of invasive squamous cell carcinoma (ISCC). ANXA1 expression was strong in normal cervical squamous epithelium and significantly reduced with increasing progression of cervical neoplasia. Moreover, a close association was observed between ANXA1 expression and tumour cell differentiation in ISCC. These preliminary results indicate that ANXA1 may be an effective candidate for detecting CIN lesions and for evaluating tumour cell differentiation in squamous cell carcinoma of the cervix.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18652761 DOI： 10.1177/147323000803600407
Source DB: PubMed Journal: J Int Med Res ISSN： 0300-0605 Impact factor: 1.671