Literature DB >> 18651771

Sesquiterpenoids from Hedyosmum orientale.

Zu-Shang Su1, Sheng Yin, Zhi-Wang Zhou, Yan Wu, Jian Ding, Jian-Min Yue.   

Abstract

Five new guaiane-type sesquiterpenoids, hedyosumins A-E (1-5), together with five known ones (6-10), were isolated from the aerial parts of Hedyosmum orientale. Two known sesquiterpenoids, 10alpha-hydroxy-1,5alpha H-guaia-3,7(11)-dien-8alpha,12-olide and 9alpha-hydroxyasterolide, were obtained as natural products for the first time. Their structures were elucidated on the basis of spectroscopic methods. 9alpha-Hydroxyasterolide (7) showed moderate activities against A-549 and HL-60 tumor cell lines with the IC 50 values of 3.1 and 8.8 microM, respectively.

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Year:  2008        PMID： 18651771     DOI： 10.1021/np800240v

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

Review 1.  Discovery of structurally diverse and bioactive compounds from plant resources in China.

Authors:  Sheng-Ping Yang; Jian-Min Yue
Journal:  Acta Pharmacol Sin       Date:  2012-09-03       Impact factor: 6.150

2.  Catalytic asymmetric synthesis of 8-oxabicyclooctanes by intermolecular [5+2] pyrylium cycloadditions.

Authors:  Michael R Witten; Eric N Jacobsen
Journal:  Angew Chem Int Ed Engl       Date:  2014-04-29       Impact factor: 15.336

3.  Gold(I) as an artificial cyclase: short stereodivergent syntheses of (-)-epiglobulol and (-)-4β,7α- and (-)-4α,7α-aromadendranediols.

Authors:  Javier Carreras; Madeleine Livendahl; Paul R McGonigal; Antonio M Echavarren
Journal:  Angew Chem Int Ed Engl       Date:  2014-04-01       Impact factor: 15.336

4.  Towards a general diastereoselective route to oxabicyclo[3.2.1]octanes via a gold-catalysed cascade reaction.

Authors:  Junkai Fu; Yueqing Gu; Hao Yuan; Tuoping Luo; Song Liu; Yu Lan; Jianxian Gong; Zhen Yang
Journal:  Nat Commun       Date:  2015-10-16       Impact factor: 14.919
  4 in total

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