Differences in aggressive behavior and in the mesocorticolimbic DA system between A/J and BALB/cJ mice.

The neurotransmitters DA and serotonin are known to be important modulators of aggression, but endogenous differences in these systems between aggressive and nonaggressive animals are poorly understood. To examine this issue, the mesocorticolimbic DA and serotonin systems of two mouse strains that differ in aggressive behavior, BALB/cJ and A/J, were analyzed using high performance liquid chromatography and quantitative receptor autoradiography. Significant differences in both serotonergic and dopaminergic systems were found between aggressive and nonaggressive mice. The nonaggressive A/J mice exhibited higher DA utilization in the nucleus accumbens and prefrontal cortex, higher D1 receptor expression in the rostral pole of the accumbens, and lower D2 receptor expression throughout the accumbens, as compared with aggressive BALB/cJ mice. Although correlative in nature, these data suggest that differences in mesocorticolimbic DA and serotonin systems may contribute to endogenous differences in aggression. (c) 2008 Wiley-Liss, Inc.