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Literature DB >> 18650518

HIV integrase inhibitors--out of the pipeline and into the clinic.

Diane V Havlir.

Abstract

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Year: 2008 PMID： 18650518 DOI： 10.1056/NEJMe0804289

Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245

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8 in total

1. Evaluation of a system to screen for stimulators of non-specific DNA nicking by HIV-1 integrase: application to a library of 50,000 compounds.

Authors: Malgorzata Sudol; Jennifer L Fritz; Melissa Tran; Gavin P Robertson; Julie B Ealy; Michael Katzman
Journal: Antivir Chem Chemother Date: 2011-10-07

2. Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.

Authors: Kushol Gupta; Tracy Diamond; Young Hwang; Frederic Bushman; Gregory D Van Duyne
Journal: J Biol Chem Date: 2010-04-20 Impact factor: 5.157

3. Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

Authors: Kushol Gupta; Joseph E Curtis; Susan Krueger; Young Hwang; Peter Cherepanov; Frederic D Bushman; Gregory D Van Duyne
Journal: Structure Date: 2012-09-20 Impact factor: 5.006

4. Trends in multidrug treatment failure and subsequent mortality among antiretroviral therapy-experienced patients with HIV infection in North America.

Authors: Steven G Deeks; Stephen J Gange; Mari M Kitahata; Michael S Saag; Amy C Justice; Robert S Hogg; Joseph J Eron; John T Brooks; Sean B Rourke; M John Gill; Ronald J Bosch; Constance A Benson; Ann C Collier; Jeffrey N Martin; Marina B Klein; Lisa P Jacobson; Benigno Rodriguez; Timothy R Sterling; Gregory D Kirk; Sonia Napravnik; Anita R Rachlis; Liviana M Calzavara; Michael A Horberg; Michael J Silverberg; Kelly A Gebo; Margot B Kushel; James J Goedert; Rosemary G McKaig; Richard D Moore
Journal: Clin Infect Dis Date: 2009-11-15 Impact factor: 9.079

HIV integrase inhibitors--out of the pipeline and into the clinic.

1. Evaluation of a system to screen for stimulators of non-specific DNA nicking by HIV-1 integrase: application to a library of 50,000 compounds.

2. Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.

3. Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

4. Trends in multidrug treatment failure and subsequent mortality among antiretroviral therapy-experienced patients with HIV infection in North America.

Review 5. Raltegravir: in treatment-naive patients with HIV-1 infection.

6. A nonradioactive plate-based assay for stimulators of nonspecific DNA nicking by HIV-1 integrase and other nucleases.

7. Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cure.

Review 8. The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures.