Literature DB >> 18650379

S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity.

Jing Tian1, Sangwon F Kim, Lynda Hester, Solomon H Snyder.   

Abstract

Glutamate/N-methyl-d-aspartate (NMDA) receptor-mediated neurotoxicity involves cyclooxygenase (COX)-2. We demonstrate that this neurotoxicity reflects activation of COX-2 by S-nitrosylation after selective binding of neuronal nitric oxide synthase (nNOS) to COX-2. nNOS, via its PDZ domain, binds COX-2 with the generated NO S-nitrosylating and activating the enzyme. Selective disruption of nNOS-COX-2 binding prevents NMDA neurotoxicity.

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Year:  2008        PMID： 18650379      PMCID： PMC2492460          DOI： 10.1073/pnas.0804852105

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1996-03-19       Impact factor: 11.205

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Journal:  Nat Rev Drug Discov       Date:  2003-03       Impact factor: 84.694

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Journal:  Annu Rev Biophys Biomol Struct       Date:  2003-02-05

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  42 in total

1.  Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal cyclooxygenase-2 function, lipid peroxidation, and neuroprotection.

Authors:  David T Stark; Nicolas G Bazan
Journal:  J Neurosci       Date:  2011-09-28       Impact factor: 6.167

Review 2.  Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases.

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Journal:  Exp Neurol       Date:  2012-07-05       Impact factor: 5.330

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Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-07-05       Impact factor: 6.237

Review 4.  The role of nitric oxide in prostaglandin biology; update.

Authors:  Sangwon F Kim
Journal:  Nitric Oxide       Date:  2011-07-26       Impact factor: 4.427

Review 5.  Integrating cytosolic phospholipase A₂ with oxidative/nitrosative signaling pathways in neurons: a novel therapeutic strategy for AD.

Authors:  Grace Y Sun; Yan He; Dennis Y Chuang; James C Lee; Zezong Gu; Agnes Simonyi; Albert Y Sun
Journal:  Mol Neurobiol       Date:  2012-04-03       Impact factor: 5.590

Review 6.  Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications.

Authors:  Daniela Salvemini; Sangwon F Kim; Vincenzo Mollace
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2013-02-06       Impact factor: 3.619

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Authors:  Tomohiro Nakamura; Shichun Tu; Mohd Waseem Akhtar; Carmen R Sunico; Shu-Ichi Okamoto; Stuart A Lipton
Journal:  Neuron       Date:  2013-05-22       Impact factor: 17.173

Review 8.  Nitrosothiols in the immune system: signaling and protection.

Authors:  Pablo Hernansanz-Agustín; Alicia Izquierdo-Álvarez; Almudena García-Ortiz; Sales Ibiza; Juan M Serrador; Antonio Martínez-Ruiz
Journal:  Antioxid Redox Signal       Date:  2012-08-17       Impact factor: 8.401

9.  Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells.

Authors:  Tongzheng Liu; Ryan A Schneider; Vaibhav Shah; Yongcheng Huang; Rostislav I Likhotvorik; Lakhu Keshvara; Dale G Hoyt
Journal:  J Inflamm (Lond)       Date:  2009-06-22       Impact factor: 4.981

10.  Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide.

Authors:  Jingshan Lu; Tayo Katano; Emiko Okuda-Ashitaka; Yo Oishi; Yoshihiro Urade; Seiji Ito
Journal:  Mol Pain       Date:  2009-09-29       Impact factor: 3.395
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