Literature DB >> 18649274

Ion channels that control fertility in mammalian spermatozoa.

Betsy Navarro1, Yuriy Kirichok, Jean-Ju Chung, David E Clapham.   

Abstract

Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible. This review summarizes the ion channel currents that have been directly measured in mammalian sperm, and their physiological roles in fertilization. The predominant currents are a Ca2+-selective current requiring expression of the 4 mCatSper genes, and a rectifying K+ current with properties most similar to mSlo3. Intracellular alkalinization activates both channels and induces hyperactivated motility.

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Year:  2008        PMID： 18649274      PMCID： PMC4297656          DOI： 10.1387/ijdb.072554bn

Source DB:  PubMed          Journal:  Int J Dev Biol        ISSN： 0214-6282            Impact factor:   2.203


  49 in total

1.  Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit.

Authors:  K Jun; E S Piedras-Rentería; S M Smith; D B Wheeler; S B Lee; T G Lee; H Chin; M E Adams; R H Scheller; R W Tsien; H S Shin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

2.  Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels.

Authors:  D Kim; I Song; S Keum; T Lee; M J Jeong; S S Kim; M W McEnery; H S Shin
Journal:  Neuron       Date:  2001-07-19       Impact factor: 17.173

3.  Hyperactivated sperm motility driven by CatSper2 is required for fertilization.

Authors:  Timothy A Quill; Sarah A Sugden; Kristen L Rossi; Lynda K Doolittle; Robert E Hammer; David L Garbers
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

4.  Loss of sex discrimination and male-male aggression in mice deficient for TRP2.

Authors:  Lisa Stowers; Timothy E Holy; Markus Meister; Catherine Dulac; Georgy Koentges
Journal:  Science       Date:  2002-01-31       Impact factor: 47.728

5.  Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.

Authors:  C Seisenberger; V Specht; A Welling; J Platzer; A Pfeifer; S Kühbandner; J Striessnig; N Klugbauer; R Feil; F Hofmann
Journal:  J Biol Chem       Date:  2000-12-15       Impact factor: 5.157

6.  Sodium and epithelial sodium channels participate in the regulation of the capacitation-associated hyperpolarization in mouse sperm.

Authors:  Enrique O Hernández-González; Julian Sosnik; Jennifer Edwards; Juan José Acevedo; Irene Mendoza-Lujambio; Ignacio López-González; Ignacio Demarco; Eva Wertheimer; Alberto Darszon; Pablo E Visconti
Journal:  J Biol Chem       Date:  2005-12-30       Impact factor: 5.157

Review 7.  [Ca2+]i signalling in sperm--making the most of what you've got.

Authors:  Stephen Publicover; Claire V Harper; Christopher Barratt
Journal:  Nat Cell Biol       Date:  2007-03       Impact factor: 28.824

8.  Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3.

Authors:  M Biel; M Seeliger; A Pfeifer; K Kohler; A Gerstner; A Ludwig; G Jaissle; S Fauser; E Zrenner; F Hofmann
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-22       Impact factor: 11.205

9.  A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC).

Authors:  Dan Wang; Jie Hu; I Alexandru Bobulescu; Timothy A Quill; Paul McLeroy; Orson W Moe; David L Garbers
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-17       Impact factor: 11.205

10.  A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility.

Authors:  Dan Wang; Shelby M King; Timothy A Quill; Lynda K Doolittle; David L Garbers
Journal:  Nat Cell Biol       Date:  2003-11-23       Impact factor: 28.824
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  49 in total

Review 1.  Rethinking the relationship between hyperactivation and chemotaxis in mammalian sperm.

Authors:  Haixin Chang; Susan S Suarez
Journal:  Biol Reprod       Date:  2010-05-12       Impact factor: 4.285

2.  ATP-activated P2X2 current in mouse spermatozoa.

Authors:  Betsy Navarro; Kiyoshi Miki; David E Clapham
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-10       Impact factor: 11.205

Review 3.  Genetic male infertility and mutation of CATSPER ion channels.

Authors:  Michael S Hildebrand; Matthew R Avenarius; Marc Fellous; Yuzhou Zhang; Nicole C Meyer; Jana Auer; Catherine Serres; Kimia Kahrizi; Hossein Najmabadi; Jacques S Beckmann; Richard J H Smith
Journal:  Eur J Hum Genet       Date:  2010-07-21       Impact factor: 4.246

Review 4.  The control of male fertility by spermatozoan ion channels.

Authors:  Polina V Lishko; Yuriy Kirichok; Dejian Ren; Betsy Navarro; Jean-Ju Chung; David E Clapham
Journal:  Annu Rev Physiol       Date:  2011-10-13       Impact factor: 19.318

Review 5.  Ion channels, phosphorylation and mammalian sperm capacitation.

Authors:  Pablo E Visconti; Dario Krapf; José Luis de la Vega-Beltrán; Juan José Acevedo; Alberto Darszon
Journal:  Asian J Androl       Date:  2011-05       Impact factor: 3.285

6.  Role of human Na,K-ATPase alpha 4 in sperm function, derived from studies in transgenic mice.

Authors:  Jeffrey McDermott; Gladis Sánchez; Ajay K Nangia; Gustavo Blanco
Journal:  Mol Reprod Dev       Date:  2015-01-14       Impact factor: 2.609

Review 7.  Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa.

Authors:  S Breton; A V Nair; M A Battistone
Journal:  Andrology       Date:  2019-05-01       Impact factor: 3.842

8.  Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient.

Authors:  James F Smith; Olga Syritsyna; Marc Fellous; Catherine Serres; Nadja Mannowetz; Yuriy Kirichok; Polina V Lishko
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-25       Impact factor: 11.205

9.  Sperm patch-clamp.

Authors:  Polina Lishko; David E Clapham; Betsy Navarro; Yuriy Kirichok
Journal:  Methods Enzymol       Date:  2013       Impact factor: 1.600

10.  Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation.

Authors:  Anne E Carlson; Lindsey A Burnett; Donato del Camino; Timothy A Quill; Bertil Hille; Jayhong A Chong; Magdalene M Moran; Donner F Babcock
Journal:  PLoS One       Date:  2009-08-31       Impact factor: 3.240
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