Literature DB >> 18649016

Ceramide inhibits CCN2 expression in fibroblasts.

Laura Kennedy1, Sunil Parapuram, Jill Greenspoon, Andrew Leask.   

Abstract

Connective tissue growth factor (CTGF, CCN2) is induced in response to TGFbeta in fibroblasts. In this report, we show that C2 ceramide reduced the ability of TGFbeta to induce CCN2 protein, mRNA and promoter activity in fibroblasts. C2 ceramide reduced the ability of TGFbeta to induce the generic Smad responsive promoter/reporter construct SBE-luciferase. These results suggest that C2 ceramide reduces the action of TGFbeta in fibroblasts via Smad antagonism.

Entities:  

Year:  2008        PMID： 18649016      PMCID： PMC2570009          DOI： 10.1007/s12079-008-0024-4

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  26 in total

1.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Authors:  K J Livak; T D Schmittgen
Journal:  Methods       Date:  2001-12       Impact factor: 3.608

2.  The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts.

Authors:  A Leask; S Sa; A Holmes; X Shiwen; C M Black; D J Abraham
Journal:  Mol Pathol       Date:  2001-06

3.  Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling.

Authors:  Chih-Chiun Chen; Jennifer L Young; Ricardo I Monzon; Ningyu Chen; Viktor Todorović; Lester F Lau
Journal:  EMBO J       Date:  2007-02-22       Impact factor: 11.598

4.  CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.

Authors:  Youjun Chen; Ingrid E Blom; Susan Sa; Roel Goldschmeding; David J Abraham; Andrew Leask
Journal:  Kidney Int       Date:  2002-10       Impact factor: 10.612

5.  Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts.

Authors:  Andrew Leask; Alan Holmes; Carol M Black; David J Abraham
Journal:  J Biol Chem       Date:  2003-02-05       Impact factor: 5.157

Review 6.  Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor.

Authors:  S Adam-Klages; R Schwandner; D Adam; D Kreder; K Bernardo; M Krönke
Journal:  J Leukoc Biol       Date:  1998-06       Impact factor: 4.962

7.  Treatment with alpha-galactosylceramide attenuates the development of bleomycin-induced pulmonary fibrosis.

Authors:  Toru Kimura; Yukio Ishii; Yuko Morishima; Akira Shibuya; Kazuko Shibuya; Masaru Taniguchi; Mie Mochizuki; Ahmed E Hegab; Tohru Sakamoto; Akihiro Nomura; Kiyohisa Sekizawa
Journal:  J Immunol       Date:  2004-05-01       Impact factor: 5.422

8.  CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.

Authors:  Xu Shi-wen; Lee Anne Stanton; Laura Kennedy; Daphne Pala; Yunliang Chen; Sarah L Howat; Elisabetta A Renzoni; David E Carter; George Bou-Gharios; Richard J Stratton; Jeremy D Pearson; Frank Beier; Karen M Lyons; Carol M Black; David J Abraham; Andrew Leask
Journal:  J Biol Chem       Date:  2006-02-16       Impact factor: 5.157

9.  CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.

Authors:  Yunliang Chen; David J Abraham; Xu Shi-Wen; Jeremy D Pearson; Carol M Black; Karen M Lyons; Andrew Leask
Journal:  Mol Biol Cell       Date:  2004-09-15       Impact factor: 4.138

10.  Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

Authors:  A Igarashi; H Okochi; D M Bradham; G R Grotendorst
Journal:  Mol Biol Cell       Date:  1993-06       Impact factor: 4.138
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  1 in total

1.  Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

Authors:  Andrew Leask; Sunil K Parapuram; Xu Shi-Wen; D J Abraham
Journal:  J Cell Commun Signal       Date:  2009-01-21       Impact factor: 5.782
  1 in total

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