BACKGROUND: Extraovarian yolk sac tumors (YSTs) arising in the omentum represent an exceedingly rare malignancy. CASE: A 37-year-old Korean woman was admitted with a history of lower abdominal pain of 3 weeks duration. Pelvic computerized tomography (CT) scanning reported a bilateral ovarian malignancy with peritoneal seeding. Exploration findings revealed a greater omental mass and the result of frozen biopsy was adenocarcinoma or mesothelioma. She was treated with supracolic omentectomy, bilateral salpingo-oophorectomy, pelvic and paraaortic lymph node dissection, multiple peritoneal biopsies and appendectomy. Histological evaluation of the specimen after operation exhibited typical patterns of YST and stained for alpha-fetoprotein (AFP) and cytokeratin. Four courses of bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy repeated every 3 weeks were added to therapy and she has remained free of disease for 1 year after completion of the therapy. CONCLUSION: To our knowledge this is the fourth case of primary omental YST. A review of the literature indicates that the diagnosis of YST requires proper evaluations of tumor makers and a skilled pathologist for analysis of frozen sections.
BACKGROUND: Extraovarian yolk sac tumors (YSTs) arising in the omentum represent an exceedingly rare malignancy. CASE: A 37-year-old Korean woman was admitted with a history of lower abdominal pain of 3 weeks duration. Pelvic computerized tomography (CT) scanning reported a bilateral ovarian malignancy with peritoneal seeding. Exploration findings revealed a greater omental mass and the result of frozen biopsy was adenocarcinoma or mesothelioma. She was treated with supracolic omentectomy, bilateral salpingo-oophorectomy, pelvic and paraaortic lymph node dissection, multiple peritoneal biopsies and appendectomy. Histological evaluation of the specimen after operation exhibited typical patterns of YST and stained for alpha-fetoprotein (AFP) and cytokeratin. Four courses of bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy repeated every 3 weeks were added to therapy and she has remained free of disease for 1 year after completion of the therapy. CONCLUSION: To our knowledge this is the fourth case of primary omental YST. A review of the literature indicates that the diagnosis of YST requires proper evaluations of tumor makers and a skilled pathologist for analysis of frozen sections.
Authors: Daniela Fischerova; Tereza Indrielle-Kelly; Andrea Burgetova; Rosalie Jana Bennett; Maria Gregova; Pavel Dundr; Ondrej Nanka; Giulia Gambino; Filip Frühauf; Roman Kocian; Martina Borcinova; David Cibula Journal: Diagnostics (Basel) Date: 2022-01-25
Authors: Wing Ho Mui; Ka Chai Lee; Sin Chuen Chiu; Chun Yin Pang; Sau Kwan Chu; Chi Wai Man; Chi Sing Wong; Wing Kin Sze; Yuk Tung Journal: Oncol Lett Date: 2013-11-08 Impact factor: 2.967