Literature DB >> 18648555

Radiological emergency response: the National Biological Dosimetry Response Plan.

J A Dolling1, D R Boreham.   

Abstract

This presentation will discuss new developments in emergency biological dosimetry and the CRTI (CBRN Research and Technology Initiative) National Biological Dosimetry Response Plan (NBDRP). Biological dosimetry is a technique used to estimate the biological consequences of a radiation exposure and is largely based on chromosome aberration detection. The NBDRP will establish a national network of laboratories to respond to a nuclear event for the purposes of rapid radiation dose estimation for crisis management and for long-term health risk assessment. In the event of a large-scale radiation accident or deliberate act of terrorism this will help guide the actions of emergency officials, emergency responders and health care personnel by providing timely biological dose estimates. The presentation will outline the research initiatives to develop modern techniques used for biological dosimetry. The overall purpose of this presentation is to provide the audience with a brief introduction to radiobiology, radiation-induced DNA damage, the health risks associated with radiation exposure, and the latest cytogenetic techniques used to estimate the risk.

Year:  2006        PMID: 18648555      PMCID: PMC2477706          DOI: 10.2203/dose-response.06-107.Dolling

Source DB:  PubMed          Journal:  Dose Response        ISSN: 1559-3258            Impact factor:   2.658


  4 in total

1.  The role of cytogenetics in early triage of radiation casualties.

Authors:  D C Lloyd; A A Edwards; J E Moquet; Y C Guerrero-Carbajal
Journal:  Appl Radiat Isot       Date:  2000-05       Impact factor: 1.513

2.  Quantification of low dose signal in EPR tooth dosimetry--a novel approach.

Authors:  R F H Khan; D R Boreham; W J Rink
Journal:  Radiat Prot Dosimetry       Date:  2003       Impact factor: 0.972

3.  Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping.

Authors:  T Veldman; C Vignon; E Schröck; J D Rowley; T Ried
Journal:  Nat Genet       Date:  1997-04       Impact factor: 38.330

4.  Induction of premature chromosome condensation by a phosphatase inhibitor and a protein kinase in unstimulated human peripheral blood lymphocytes: a simple and rapid technique to study chromosome aberrations using specific whole-chromosome DNA hybridization probes for biological dosimetry.

Authors:  P G Prasanna; N D Escalada; W F Blakely
Journal:  Mutat Res       Date:  2000-03-23       Impact factor: 2.433

  4 in total

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