AIMS: Some studies show coronary heart disease (CHD) to be a risk factor for cognitive function while others report no association between the two. We examined the effect of CHD history and duration on cognition in a middle-aged population. METHODS AND RESULTS: Data come from the Whitehall II study of 10,308 participants (33% women), aged 35-55 years at baseline (Phase 1; 1985-88). CHD events were assessed up to Phase 7 (2002-04) when 5837 participants (28.4% women) undertook six cognitive tests: reasoning, vocabulary, phonemic and semantic fluency, memory and the mini-mental-state-examination (MMSE); standardized to T-scores (mean = 50, standard deviation = 10). Analysis of covariance was used first to model the association between CHD history and cognition and then to examine the effect of time since first CHD event (in the last 5 years, 5-10 years ago, >10 years ago). Among men, in analyses adjusted for age, education, marital status and medication for cardiovascular disease, CHD history was associated with lower T-scores on reasoning [-1.16; 95% confidence interval (CI) = -2.07, -0.25], vocabulary (-2.11; 95% CI = -3.01, -1.21), and the MMSE (-1.45; 95% CI = -2.42, -0.49). In women, these effects were also evident for phonemic and semantic fluency. Among men, the trend within CHD cases suggested progressively lower scores on reasoning, vocabulary and semantic fluency among those with longer duration of CHD. CONCLUSION: Our findings go some way towards suggesting an association between CHD history and cognitive performance in middle-aged adults.
AIMS: Some studies show coronary heart disease (CHD) to be a risk factor for cognitive function while others report no association between the two. We examined the effect of CHD history and duration on cognition in a middle-aged population. METHODS AND RESULTS: Data come from the Whitehall II study of 10,308 participants (33% women), aged 35-55 years at baseline (Phase 1; 1985-88). CHD events were assessed up to Phase 7 (2002-04) when 5837 participants (28.4% women) undertook six cognitive tests: reasoning, vocabulary, phonemic and semantic fluency, memory and the mini-mental-state-examination (MMSE); standardized to T-scores (mean = 50, standard deviation = 10). Analysis of covariance was used first to model the association between CHD history and cognition and then to examine the effect of time since first CHD event (in the last 5 years, 5-10 years ago, >10 years ago). Among men, in analyses adjusted for age, education, marital status and medication for cardiovascular disease, CHD history was associated with lower T-scores on reasoning [-1.16; 95% confidence interval (CI) = -2.07, -0.25], vocabulary (-2.11; 95% CI = -3.01, -1.21), and the MMSE (-1.45; 95% CI = -2.42, -0.49). In women, these effects were also evident for phonemic and semantic fluency. Among men, the trend within CHD cases suggested progressively lower scores on reasoning, vocabulary and semantic fluency among those with longer duration of CHD. CONCLUSION: Our findings go some way towards suggesting an association between CHD history and cognitive performance in middle-aged adults.
Authors: M K Aronson; W L Ooi; H Morgenstern; A Hafner; D Masur; H Crystal; W H Frishman; D Fisher; R Katzman Journal: Neurology Date: 1990-07 Impact factor: 9.910
Authors: Philip Greenland; Maria Deloria Knoll; Jeremiah Stamler; James D Neaton; Alan R Dyer; Daniel B Garside; Peter W Wilson Journal: JAMA Date: 2003-08-20 Impact factor: 56.272
Authors: Umesh N Khot; Monica B Khot; Christopher T Bajzer; Shelly K Sapp; E Magnus Ohman; Sorin J Brener; Stephen G Ellis; A Michael Lincoff; Eric J Topol Journal: JAMA Date: 2003-08-20 Impact factor: 56.272
Authors: Angelina R Sutin; Antonio Terracciano; Melissa H Kitner-Triolo; Manuela Uda; David Schlessinger; Alan B Zonderman Journal: Psychol Aging Date: 2011-06-27
Authors: Jane E Ferrie; Martin J Shipley; Tasnime N Akbaraly; Michael G Marmot; Mika Kivimäki; Archana Singh-Manoux Journal: Sleep Date: 2011-05-01 Impact factor: 5.849
Authors: Sara G Murray; Jinoos Yazdany; Rachel Kaiser; Lindsey A Criswell; Laura Trupin; Edward H Yelin; Patricia P Katz; Laura J Julian Journal: Arthritis Care Res (Hoboken) Date: 2012-09 Impact factor: 4.794
Authors: M Jokela; A Singh-Manoux; J E Ferrie; D Gimeno; T N Akbaraly; M J Shipley; J Head; M Elovainio; M G Marmot; M Kivimäki Journal: Psychol Med Date: 2009-09-01 Impact factor: 7.723
Authors: Marianna Virtanen; Archana Singh-Manoux; Jane E Ferrie; David Gimeno; Michael G Marmot; Marko Elovainio; Markus Jokela; Jussi Vahtera; Mika Kivimäki Journal: Am J Epidemiol Date: 2009-01-06 Impact factor: 4.897