OBJECTIVE: To perform an evaluation of selected phytochemicals intake and breast cancer (BC) risk in Mexican women. DESIGN: We conducted hospital-based case-control study. SETTING: Mexico City between 1994 and 1996. SUBJECTS: A total of 141 histologically confirmed BC cases were age-matched (+/-3 years) to an equal number of hospital controls. The reproductive history of each woman was obtained by direct interview. The dietary consumption of flavonols, flavones, flavan-3-ols, cinnamic acid, lariciresinol, pinoresinol, secoisolariciresinol, matairesinol and coumestrol was obtained by means of a validated FFQ. RESULTS: Among postmenopausal women, high dietary intake of flavonols and flavones was associated with a significant reduction of BC risk (high v. low tertile: OR = 0.21, 95 % CI 0.07, 0.60, P for trend = 0.004 and OR = 0.29, 95 % CI 0.10, 0.82, P for trend = 0.025, respectively); consumption of lignans (lariciresinol and pinoresinol) showed a similar effect, but only among premenopausal women (high v. low tertile: OR = 0.32, 95 % CI 0.10, 0.99, P for trend = 0.051 and OR = 0.19, 95 % CI 0.06, 0.62, P for trend = 0.006, respectively). CONCLUSIONS: Our results support a protective role of specific dietary phytochemicals in BC risk by menopausal status, independent of other reproductive factors.
OBJECTIVE: To perform an evaluation of selected phytochemicals intake and breast cancer (BC) risk in Mexican women. DESIGN: We conducted hospital-based case-control study. SETTING: Mexico City between 1994 and 1996. SUBJECTS: A total of 141 histologically confirmed BC cases were age-matched (+/-3 years) to an equal number of hospital controls. The reproductive history of each woman was obtained by direct interview. The dietary consumption of flavonols, flavones, flavan-3-ols, cinnamic acid, lariciresinol, pinoresinol, secoisolariciresinol, matairesinol and coumestrol was obtained by means of a validated FFQ. RESULTS: Among postmenopausal women, high dietary intake of flavonols and flavones was associated with a significant reduction of BC risk (high v. low tertile: OR = 0.21, 95 % CI 0.07, 0.60, P for trend = 0.004 and OR = 0.29, 95 % CI 0.10, 0.82, P for trend = 0.025, respectively); consumption of lignans (lariciresinol and pinoresinol) showed a similar effect, but only among premenopausal women (high v. low tertile: OR = 0.32, 95 % CI 0.10, 0.99, P for trend = 0.051 and OR = 0.19, 95 % CI 0.06, 0.62, P for trend = 0.006, respectively). CONCLUSIONS: Our results support a protective role of specific dietary phytochemicals in BC risk by menopausal status, independent of other reproductive factors.
Authors: Karina M Chávez-Suárez; María I Ortega-Vélez; Ana I Valenzuela-Quintanar; Marcia Galván-Portillo; Lizbeth López-Carrillo; Julián Esparza-Romero; María S Saucedo-Tamayo; María R Robles-Burgueño; Susana A Palma-Durán; María L Gutiérrez-Coronado; Melissa M Campa-Siqueiros; Patricia Grajeda-Cota; Graciela Caire-Juvera Journal: Nutrients Date: 2017-09-29 Impact factor: 5.717