BACKGROUND: Surgery utilizing an enamel matrix protein derivative (EMD) or guided tissue regeneration (GTR) has been shown to promote periodontal regeneration. AIM: To evaluate the 10-year results following treatment with EMD, GTR, EMD+GTR, and open flap debridement (OFD). MATERIAL AND METHODS: Thirty-eight patients out of an initial group of 56 participants were treated with one of the four modalities. Results were evaluated before surgery, at 1 year, and at 10 years. Primary outcome variable was CAL change. RESULTS: Treatment with EMD yielded a mean CAL gain of 3.4+/-1.0 mm (p<0.001) and 2.9+/-1.4 mm (p<0.001) at 1 and 10 years, respectively. GTR resulted in a mean CAL gain of 3.2+/-1.4 (p<0.001) at 1 year and 2.8+/-1.2 mm (p<0.001) at 10 years. Mean CAL gain in the EMD+GTR group was of 3.3+/-1.1 mm (p<0.001) and 2.9+/-1.2 mm (p<0.001) at 1 and 10 years, respectively. Treatment with OFD demonstrated a mean CAL gain of 2.0+/-1.2 mm (p<0.01) at 1 year and 1.8+/-1.1 mm (p<0.01) at 10 years. Compared with OFD, the three regenerative treatments resulted in statistically significant (p<0.05) higher CAL gain, at both 1 and 10 years. The CAL change between 1 and 10 years did not present statistically significant differences in any of the four groups. CONCLUSION: The present results indicate that the clinical outcomes obtained with all four approaches can be maintained over a period of 10 years.
BACKGROUND: Surgery utilizing an enamel matrix protein derivative (EMD) or guided tissue regeneration (GTR) has been shown to promote periodontal regeneration. AIM: To evaluate the 10-year results following treatment with EMD, GTR, EMD+GTR, and open flap debridement (OFD). MATERIAL AND METHODS: Thirty-eight patients out of an initial group of 56 participants were treated with one of the four modalities. Results were evaluated before surgery, at 1 year, and at 10 years. Primary outcome variable was CAL change. RESULTS: Treatment with EMD yielded a mean CAL gain of 3.4+/-1.0 mm (p<0.001) and 2.9+/-1.4 mm (p<0.001) at 1 and 10 years, respectively. GTR resulted in a mean CAL gain of 3.2+/-1.4 (p<0.001) at 1 year and 2.8+/-1.2 mm (p<0.001) at 10 years. Mean CAL gain in the EMD+GTR group was of 3.3+/-1.1 mm (p<0.001) and 2.9+/-1.2 mm (p<0.001) at 1 and 10 years, respectively. Treatment with OFD demonstrated a mean CAL gain of 2.0+/-1.2 mm (p<0.01) at 1 year and 1.8+/-1.1 mm (p<0.01) at 10 years. Compared with OFD, the three regenerative treatments resulted in statistically significant (p<0.05) higher CAL gain, at both 1 and 10 years. The CAL change between 1 and 10 years did not present statistically significant differences in any of the four groups. CONCLUSION: The present results indicate that the clinical outcomes obtained with all four approaches can be maintained over a period of 10 years.
Authors: Barbara J Tarasevich; John S Philo; Nasib Karl Maluf; Susan Krueger; Garry W Buchko; Genyao Lin; Wendy J Shaw Journal: J Struct Biol Date: 2014-10-25 Impact factor: 2.867
Authors: Marco Esposito; Maria Gabriella Grusovin; Nikolaos Papanikolaou; Paul Coulthard; Helen V Worthington Journal: Cochrane Database Syst Rev Date: 2009-10-07
Authors: Thomas De Bruyckere; Aryan Eghbali; Faris Younes; Roberto Cleymaet; Wolfgang Jacquet; Hugo De Bruyn; Jan Cosyn Journal: Clin Oral Investig Date: 2017-09-30 Impact factor: 3.573
Authors: Richard J Miron; Erik Hedbom; Sabrina Ruggiero; Dieter D Bosshardt; Yufeng Zhang; Corinna Mauth; Anja C Gemperli; Tateyuki Iizuka; Daniel Buser; Anton Sculean Journal: PLoS One Date: 2011-08-15 Impact factor: 3.240
Authors: Christoph Reichert; Bilal Al-Nawas; Ralf Smeets; Adrian Kasaj; Werner Götz; Marcus O Klein Journal: Head Face Med Date: 2009-11-12 Impact factor: 2.151