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Literature DB >> 18646774

Cladoniamides A-G, tryptophan-derived alkaloids produced in culture by Streptomyces uncialis.

David E Williams¹, Julian Davies, Brian O Patrick, Helen Bottriell, Tamsin Tarling, Michel Roberge, Raymond J Andersen.

Abstract

Cladoniamides A-G (3- 9) have been isolated from cultures of Streptomyces uncialis, and their structures have been elucidated by a combination of spectroscopic analysis and an X-ray diffraction analysis of cladoniamide A (3). The cladoniamides have unprecedented rearranged and degraded alkaloid skeletons with putative biogenetic origins from indolocarbazole precursors. Cladoniamide G (9) is cytotoxic to MCF-7 cells in vitro at 10 microg/mL.

Entities: Chemical Species

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Year: 2008 PMID： 18646774 DOI： 10.1021/ol801274c

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

18 in total

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4. Diversity, Antimicrobial Activity, and Biosynthetic Potential of Cultivable Actinomycetes Associated with Lichen Symbiosis.

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10. Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017.

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Cladoniamides A-G, tryptophan-derived alkaloids produced in culture by Streptomyces uncialis.

1. Streptomyces adelaidensis sp. nov., an actinobacterium isolated from the root of Callitris preissii with potential for plant growth-promoting properties.

2. Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.

3. Bacterial diversity across individual lichens.

4. Diversity, Antimicrobial Activity, and Biosynthetic Potential of Cultivable Actinomycetes Associated with Lichen Symbiosis.

5. Screening of mutant strain Streptomyces mediolani sp. AC37 for (-)-8-O-methyltetrangomycin production enhancement.

6. Reconstruction of cladoniamide biosynthesis reveals nonenzymatic routes to bisindole diversity.

7. Expansion of bisindole biosynthetic pathways by combinatorial construction.

8. Divergent pathways in the biosynthesis of bisindole natural products.

9. Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.

10. Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017.