Literature DB >> 18646773

Convergent synthesis and biological activity of the WXYZA'B'C' ring system of maitotoxin.

Tohru Oishi1, Futoshi Hasegawa, Kohei Torikai, Keiichi Konoki, Nobuaki Matsumori, Michio Murata.   

Abstract

The WXYZA'B'C' ring system ( 1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C' ring fragments through construction of the XY and A'B' ring systems. The synthetic segment 1 blocked the hemolytic activity elicited by MTX.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18646773     DOI： 10.1021/ol801369g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Maitotoxin: An Inspiration for Synthesis.

Authors:  K C Nicolaou; Robert J Aversa
Journal:  Isr J Chem       Date:  2011-04       Impact factor: 3.333

2.  Synthesis of the WXYZA' domain of maitotoxin.

Authors:  K C Nicolaou; Thomas M Baker; Tsuyoshi Nakamura
Journal:  J Am Chem Soc       Date:  2010-12-17       Impact factor: 15.419

3.  Synthesis of the C'D'E'F' domain of maitotoxin.

Authors:  K C Nicolaou; Jae Hong Seo; Tsuyoshi Nakamura; Robert J Aversa
Journal:  J Am Chem Soc       Date:  2010-12-17       Impact factor: 15.419

4.  Synthesis and biological evaluation of QRSTUVWXYZA' domains of maitotoxin.

Authors:  K C Nicolaou; Philipp Heretsch; Tsuyoshi Nakamura; Anna Rudo; Michio Murata; Keiichi Konoki
Journal:  J Am Chem Soc       Date:  2014-11-06       Impact factor: 15.419

5.  Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels.

Authors:  Keiichi Konoki; Daniel G Baden; Todd Scheuer; William A Catterall
Journal:  Toxins (Basel)       Date:  2019-09-03       Impact factor: 4.546

Review 6.  Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches.

Authors:  Paula González-Andrés; Laura Fernández-Peña; Carlos Díez-Poza; Carlos Villalobos; Lucía Nuñez; Asunción Barbero
Journal:  Mar Drugs       Date:  2021-01-31       Impact factor: 5.118
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.