Literature DB >> 18644968

Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.

Juan Fernando Alzate1, Andrés Arias, Faustino Mollinedo, Eva Rico, Janis de la Iglesia-Vicente, Antonio Jiménez-Ruiz.   

Abstract

The alkyl-lysophospholipids edelfosine and miltefosine induce apoptosis in Leishmania infantum promastigotes. The finding that edelfosine-induced cell death can be regulated by the ectopic expression of the antiapoptotic and proapoptotic members of the Bcl-2 family of proteins Bcl-X(L) and Hrk suggests that this process is similar to apoptosis in eukaryotic cells.

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Year:  2008        PMID： 18644968      PMCID： PMC2565883          DOI： 10.1128/AAC.01665-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Development status of miltefosine as first oral drug in visceral and cutaneous leishmaniasis.

Authors:  Richard D. Pearson
Journal:  Curr Infect Dis Rep       Date:  2003-02       Impact factor: 3.725

2.  Programmed cell death in the unicellular protozoan parasite Leishmania.

Authors:  N Lee; S Bertholet; A Debrabant; J Muller; R Duncan; H L Nakhasi
Journal:  Cell Death Differ       Date:  2002-01       Impact factor: 15.828

3.  Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes.

Authors:  D Sereno; P Holzmuller; I Mangot; G Cuny; A Ouaissi; J L Lemesre
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

4.  Heat-induced programmed cell death in Leishmania infantum is reverted by Bcl-X(L) expression.

Authors:  J F Alzate; A Alvarez-Barrientos; V M González; A Jiménez-Ruiz
Journal:  Apoptosis       Date:  2006-02       Impact factor: 4.677

5.  Mitochondrial superoxide mediates heat-induced apoptotic-like death in Leishmania infantum.

Authors:  Juan F Alzate; Andrés A Arias; David Moreno-Mateos; Alberto Alvarez-Barrientos; Antonio Jiménez-Ruiz
Journal:  Mol Biochem Parasitol       Date:  2007-01-09       Impact factor: 1.759

6.  Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania.

Authors:  H Lux; N Heise; T Klenner; D Hart; F R Opperdoes
Journal:  Mol Biochem Parasitol       Date:  2000-11       Impact factor: 1.759

7.  Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction.

Authors:  Navin K Verma; Gaganmeet Singh; Chinmoy S Dey
Journal:  Exp Parasitol       Date:  2006-12-11       Impact factor: 2.011

8.  Possible mechanism of miltefosine-mediated death of Leishmania donovani.

Authors:  Navin K Verma; Chinmoy S Dey
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

9.  Heat shock induction of apoptosis in promastigotes of the unicellular organism Leishmania (Leishmania) amazonensis.

Authors:  M E Moreira; H A Del Portillo; R V Milder; J M Balanco; M A Barcinski
Journal:  J Cell Physiol       Date:  1996-05       Impact factor: 6.384

10.  Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes.

Authors:  Caroline Paris; Philippe M Loiseau; Christian Bories; Jaqueline Bréard
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191
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  8 in total

1.  Antileishmanial activity of imidothiocarbamates and imidoselenocarbamates.

Authors:  David Moreno; Daniel Plano; Ylenia Baquedano; Antonio Jiménez-Ruiz; Juan Antonio Palop; Carmen Sanmartín
Journal:  Parasitol Res       Date:  2010-10-05       Impact factor: 2.289

2.  Apoptotic markers in protozoan parasites.

Authors:  Antonio Jiménez-Ruiz; Juan Fernando Alzate; Ewan Thomas Macleod; Carsten Günter Kurt Lüder; Nicolas Fasel; Hilary Hurd
Journal:  Parasit Vectors       Date:  2010-11-09       Impact factor: 3.876

3.  Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death.

Authors:  Despina Smirlis; Michael Duszenko; Antonio Jiménez Ruiz; Effie Scoulica; Patrick Bastien; Nicolas Fasel; Ketty Soteriadou
Journal:  Parasit Vectors       Date:  2010-11-17       Impact factor: 3.876

4.  Plasmodium falciparum metacaspase PfMCA-1 triggers a z-VAD-fmk inhibitable protease to promote cell death.

Authors:  Benoît Meslin; Abdoul H Beavogui; Nicolas Fasel; Stéphane Picot
Journal:  PLoS One       Date:  2011-08-17       Impact factor: 3.240

5.  Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease.

Authors:  Carlos Genes; Eduard Baquero; Fernando Echeverri; Juan D Maya; Omar Triana
Journal:  Parasit Vectors       Date:  2011-05-06       Impact factor: 3.876

6.  Decoding the anti-Trypanosoma cruzi action of HIV peptidase inhibitors using epimastigotes as a model.

Authors:  Leandro S Sangenito; Rubem F S Menna-Barreto; Claudia M D Avila-Levy; André L S Santos; Marta H Branquinha
Journal:  PLoS One       Date:  2014-12-02       Impact factor: 3.240

Review 7.  New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites.

Authors:  Jose A Garcia-Salcedo; Juan D Unciti-Broceta; Javier Valverde-Pozo; Miguel Soriano
Journal:  Front Pharmacol       Date:  2016-09-28       Impact factor: 5.810

8.  Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasis.

Authors:  Alireza Badirzadeh; Maryam Heidari-Kharaji; Vahid Fallah-Omrani; Hossein Dabiri; Atefeh Araghi; Alireza Salimi Chirani
Journal:  PLoS Negl Trop Dis       Date:  2020-01-13
  8 in total

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