Literature DB >> 18644634

Effect of IgG immunoadsorption on serum cytokines in MG and LEMS patients.

Fulvio Baggi1, Federica Ubiali, Sara Nava, Valeria Nessi, Francesca Andreetta, Andrea Rigamonti, Lorenzo Maggi, Renato Mantegazza, Carlo Antozzi.   

Abstract

We investigated the effect of IgG immunoadsorption (IA) on cytokine network in patients with treatment-resistant Myasthenia Gravis (MG) and Lambert-Eaton Syndrome (LEMS). We observed upregulation of interleukin (IL)-10, an anti-inflammatory and B cells growth factor, and reduction of pro-inflammatory factors such as IL-18 and IL-17, in both MG and LEMS after IA. Our observation suggests that the massive removal of antibodies might induce modifications of the cytokine balance linked to T and B cells mediated autoimmunity.

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Year:  2008        PMID： 18644634     DOI： 10.1016/j.jneuroim.2008.05.026

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  7 in total

1.  Mediastinal small cell cancer associated with Lambert-Eaton myasthenic syndrome: A case report.

Authors:  Kejian Zhang; Wei Liu; Yang Li; Kewei Zhang; Xinliang Gao; Jing Wang
Journal:  Exp Ther Med       Date:  2015-04-27       Impact factor: 2.447

2.  Immunoadsorption Improves Remission Rates of Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and Severe Kidney Involvement.

Authors:  Xiaoxin Chu; Yu Hong; Yuxi Wang; Chong Yu; Lisheng Wang; Hui Tong; Jianjun Yan; Zhonghua Zhang; Gang Xu; Ying Yao; Rui Zeng
Journal:  Am J Nephrol       Date:  2021-12-07       Impact factor: 3.754

3.  Inflammation and epstein-barr virus infection are common features of myasthenia gravis thymus: possible roles in pathogenesis.

Authors:  Paola Cavalcante; Lorenzo Maggi; Lara Colleoni; Rosa Caldara; Teresio Motta; Carmelo Giardina; Carlo Antozzi; Sonia Berrih-Aknin; Pia Bernasconi; Renato Mantegazza
Journal:  Autoimmune Dis       Date:  2011-09-26

Review 4.  Therapeutic Plasma Exchange: For Cancer Patients.

Authors:  Yuru Hu; Hanshan Yang; Shaozhi Fu; Jingbo Wu
Journal:  Cancer Manag Res       Date:  2022-02-02       Impact factor: 3.989

5.  Leflunomide combined with low-dose prednisone inhibits proinflammatory T cells responses in myasthenia gravis patients.

Authors:  Xin Huang; Hao Ran; Yingkia Li; Qian Ma; Changyi Ou; Li Qiu; Huiyu Feng; Weibin Liu
Journal:  Front Neurol       Date:  2022-09-09       Impact factor: 4.086

6.  Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions.

Authors:  Ingo Kleiter; Anna Gahlen; Nadja Borisow; Katrin Fischer; Klaus-Dieter Wernecke; Kerstin Hellwig; Florence Pache; Klemens Ruprecht; Joachim Havla; Tania Kümpfel; Orhan Aktas; Hans-Peter Hartung; Marius Ringelstein; Christian Geis; Christoph Kleinschnitz; Achim Berthele; Bernhard Hemmer; Klemens Angstwurm; Jan-Patrick Stellmann; Simon Schuster; Martin Stangel; Florian Lauda; Hayrettin Tumani; Christoph Mayer; Markus Krumbholz; Lena Zeltner; Ulf Ziemann; Ralf Linker; Matthias Schwab; Martin Marziniak; Florian Then Bergh; Ulrich Hofstadt-van Oy; Oliver Neuhaus; Uwe K Zettl; Jürgen Faiss; Brigitte Wildemann; Friedemann Paul; Sven Jarius; Corinna Trebst
Journal:  Neurol Neuroimmunol Neuroinflamm       Date:  2018-09-26

7.  Safety and efficacy of immunoadsorption versus plasma exchange in steroid-refractory relapse of multiple sclerosis and clinically isolated syndrome: A randomised, parallel-group, controlled trial.

Authors:  Johannes Dorst; Tanja Fangerau; Daniela Taranu; Pia Eichele; Jens Dreyhaupt; Sebastian Michels; Joachim Schuster; Albert C Ludolph; Makbule Senel; Hayrettin Tumani
Journal:  EClinicalMedicine       Date:  2019-11-14
  7 in total

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