Literature DB >> 1864307

Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909.

S Pögün1, U Scheffel, M J Kuhar.   

Abstract

Previous studies have shown that [3H] WIN 35,428 binds preferentially to striatal cocaine receptors at the dopamine transporter after in vivo injection. In vivo binding competition studies were carried out to assess the relative rates of entry and occupancy of cocaine receptors by (-)-cocaine, mazindol and GBR 12909. After i.v. injection, (-)-cocaine occupied receptors relatively more rapidly than GBR 12,909 while mazindol was the slowest.

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Year:  1991        PMID： 1864307     DOI： 10.1016/0014-2999(91)90622-w

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  The role of peripheral and central sodium channels in mediating brain temperature fluctuations induced by intravenous cocaine.

Authors:  Eugene A Kiyatkin; P Leon Brown
Journal:  Brain Res       Date:  2006-09-07       Impact factor: 3.252

2.  Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys.

Authors:  Heather L Kimmel; Joann A O'Connor; F Ivy Carroll; Leonard L Howell
Journal:  Pharmacol Biochem Behav       Date:  2006-12-20       Impact factor: 3.533

3.  Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine.

Authors:  Ken T Wakabayashi; Eugene A Kiyatkin
Journal:  J Neurochem       Date:  2013-10-28       Impact factor: 5.372

4.  Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.

Authors:  Dean G Brown; Peter R Bernstein; Ye Wu; Rebecca A Urbanek; Christopher W Becker; Scott R Throner; Bruce T Dembofsky; Gary B Steelman; Lois A Lazor; Clay W Scott; Michael W Wood; Steven S Wesolowski; David A Nugiel; Stephanie Koch; Jian Yu; Donald E Pivonka; Shuang Li; Carol Thompson; Anna Zacco; Charles S Elmore; Patricia Schroeder; JianWei Liu; Christopher A Hurley; Stuart Ward; Hazel J Hunt; Karen Williams; Joseph McLaughlin; Valerie Hoesch; Simon Sydserff; Donna Maier; David Aharony
Journal:  ACS Med Chem Lett       Date:  2012-11-12       Impact factor: 4.345

5.  Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice.

Authors:  Andrew J Mcgeehan; Patricia H Janak; M Foster Olive
Journal:  Psychopharmacology (Berl)       Date:  2004-07       Impact factor: 4.530

6.  I.v. cocaine induces rapid, transient excitation of striatal neurons via its action on peripheral neural elements: single-cell, iontophoretic study in awake and anesthetized rats.

Authors:  E A Kiyatkin; P L Brown
Journal:  Neuroscience       Date:  2007-07-17       Impact factor: 3.590

7.  Electrophysiological evaluation of the time-course of dopamine uptake inhibition induced by intravenous cocaine at a reinforcing dose.

Authors:  Y Wakazono; E A Kiyatkin
Journal:  Neuroscience       Date:  2007-12-03       Impact factor: 3.590

8.  Rate of binding of various inhibitors at the dopamine transporter in vivo.

Authors:  M Stathis; U Scheffel; S Z Lever; J W Boja; F I Carroll; M J Kuhar
Journal:  Psychopharmacology (Berl)       Date:  1995-06       Impact factor: 4.530
  8 in total

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