| Literature DB >> 18642444 |
An Wu1, Jia Chen, Renato Baserga.
Abstract
The Simian Virus 40 large T antigen (Tag) and the insulin receptor substrate-1 (IRS-1) interact with each other. Tag is a nuclear protein even in the absence of IRS-1, but IRS-1 is required for occupancy and activation by Tag of the ribosomal DNA (rDNA), cyclin D1 and c-myc promoters. Our results indicate that IRS-1 plays a significant role in Tag activation of cell cycle progression genes.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18642444 DOI： 10.4161/cc.7.13.6096
Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534