Literature DB >> 1864224

The cellular mechanism of action of bisphosphonates.

D E Hughes1, M Mian, D F Guilland-Cumming, R G Russell.   

Abstract

Present understanding of the cellular mechanism of action of bisphosphonates as in vitro and in vivo inhibitors of bone resorption is reviewed. This mechanism appears to involve the osteoclast at more than one stage of its maturation process, and way well be receptor-mediated, although the molecular mechanism itself is thus far unknown.

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Year:  1991        PMID: 1864224

Source DB:  PubMed          Journal:  Drugs Exp Clin Res        ISSN: 0378-6501


  5 in total

1.  Bisphosphonates and tetracycline: experimental models for their evaluation in calcium-related disorders.

Authors:  H Cohen; V Solomon; I S Alferiev; E Breuer; A Ornoy; N Patlas; N Eidelman; G Hägele; G Golomb
Journal:  Pharm Res       Date:  1998-04       Impact factor: 4.200

Review 2.  Targeted microbubbles: a novel application for the treatment of kidney stones.

Authors:  Krishna Ramaswamy; Vanessa Marx; Daniel Laser; Thomas Kenny; Thomas Chi; Michael Bailey; Mathew D Sorensen; Robert H Grubbs; Marshall L Stoller
Journal:  BJU Int       Date:  2015-03-17       Impact factor: 5.588

3.  Bacterial adhesion to bisphosphonate coated hydroxyapatite.

Authors:  A Ganguli; C Steward; S L Butler; G J Philips; S T Meikle; A W Lloyd; M H Grant
Journal:  J Mater Sci Mater Med       Date:  2005-04       Impact factor: 3.896

4.  The interactions of bisphosphonates in solution and as coatings on hydroxyapatite with osteoblasts.

Authors:  A Ganguli; C Henderson; M H Grant; S T Meikle; A W Lloyd; I Goldie
Journal:  J Mater Sci Mater Med       Date:  2002-10       Impact factor: 3.896

5.  Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum.

Authors:  M J Rogers; X Ji; R G Russell; G M Blackburn; M P Williamson; A V Bayless; F H Ebetino; D J Watts
Journal:  Biochem J       Date:  1994-10-01       Impact factor: 3.857

  5 in total

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