Gil Bar-Sela1, Nissim Haim. 1. Division of Oncology, Rambam-Health Care Campus, POB 9602, 31096, Haifa, Israel, g_barsela@rambam.health.gov.il
Abstract
INTRODUCTION: Capecitabine, a prodrug of 5-fluorouracil (5-FU), is rarely associated with severe hypertriglyceridemia. We present a patient with severe capcitabine-induced hypertriglyceridemia, with the literature review. CASE REPORT: A 50-year-old woman with metastatic breast carcinoma was treated with oral capecitabine. She was also receiving bezafibrate due to hyperglycenemia. Pretreatment lipid profile revealed slight elevation of serum triglycerides and total cholesterol. A repeat lipid profile performed 5 weeks after the start of capecitabine treatment revealed a marked increase in the serum triglyceride and cholesterol levels. The dose of bezafibrate was increased, atorvastatin was added, and the next cycle of capecitabine was withheld. When the triglyceride and cholesterol levels had decreased, capecitabine was started with reduced dose. However, at the end of this cycle, the triglyceride and the cholesterol levels increased again. CONCLUSION: Monitoring of the lipid profile should be considered in cancer patients receiving capecitabine, particularly those with a known diagnosis of dyslipidemia.
INTRODUCTION:Capecitabine, a prodrug of 5-fluorouracil (5-FU), is rarely associated with severe hypertriglyceridemia. We present a patient with severe capcitabine-induced hypertriglyceridemia, with the literature review. CASE REPORT: A 50-year-old woman with metastatic breast carcinoma was treated with oral capecitabine. She was also receiving bezafibrate due to hyperglycenemia. Pretreatment lipid profile revealed slight elevation of serum triglycerides and total cholesterol. A repeat lipid profile performed 5 weeks after the start of capecitabine treatment revealed a marked increase in the serum triglyceride and cholesterol levels. The dose of bezafibrate was increased, atorvastatin was added, and the next cycle of capecitabine was withheld. When the triglyceride and cholesterol levels had decreased, capecitabine was started with reduced dose. However, at the end of this cycle, the triglyceride and the cholesterol levels increased again. CONCLUSION: Monitoring of the lipid profile should be considered in cancerpatients receiving capecitabine, particularly those with a known diagnosis of dyslipidemia.