Literature DB >> 18641144

The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis.

Carleitta Paige1, Sean D Reid, Philip C Hanna, Al Claiborne.   

Abstract

In Bacillus anthracis, the novel type III pantothenate kinase (PanK(Ba); encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target.

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Year:  2008        PMID： 18641144      PMCID： PMC2546792          DOI： 10.1128/JB.00860-08

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


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