Literature DB >> 18640837

Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar.

Nwet Nwet Win1, Suresh Awale, Hiroyasu Esumi, Yasuhiro Tezuka, Shigetoshi Kadota.   

Abstract

The CHCl(3)-soluble fraction of 70% EtOH extract of the flower of Kayea assamica completely killed human pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 microg/mL. Bioassay-guided fractionation and isolation afforded two novel compounds, kayeassamins A (1) and B (2). Their structures were elucidated using extensive spectroscopic methods and the modified Mosher method. Each compound showed 100% preferential cytotoxicity (PC(100)) against PANC-1 cells under nutrient-deprived conditions at 1 microM. Furthermore, both compounds inhibited the migration of PANC-1 cells in the wound closure assay.

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Year:  2008        PMID： 18640837     DOI： 10.1016/j.bmcl.2008.07.001

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Bioactive Compounds from Medicinal Plants in Myanmar.

Authors:  Nwet Nwet Win; Hiroyuki Morita
Journal:  Prog Chem Org Nat Prod       Date:  2021

2.  EFFECT OF THAI SARAPHI FLOWER EXTRACTS ON WT1 AND BCR/ABL PROTEIN EXPRESSION IN LEUKEMIC CELL LINES.

Authors:  Rungkarn Sangkaruk; Methee Rungrojsakul; Singkome Tima; Songyot Anuchapreeda
Journal:  Afr J Tradit Complement Altern Med       Date:  2017-01-13

3.  Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar.

Authors:  Nay Lin Tun; Dong-Bao Hu; Meng-Yuan Xia; Dong-Dong Zhang; Jun Yang; Thaung Naing Oo; Yue-Hu Wang; Xue-Fei Yang
Journal:  Nat Prod Bioprospect       Date:  2019-05-07

4.  (+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death.

Authors:  Jun-ya Ueda; Sirivan Athikomkulchai; Ryuta Miyatake; Ikuo Saiki; Hiroyasu Esumi; Suresh Awale
Journal:  Drug Des Devel Ther       Date:  2013-12-18       Impact factor: 4.162

5.  Kayeassamin A Isolated from the Flower of Mammea siamensis Triggers Apoptosis by Activating Caspase-3/-8 in HL-60 Human Leukemia Cells.

Authors:  Takuhiro Uto; Nguyen Huu Tung; Pinjutha Thongjankaew; Sorasak Lhieochaiphant; Yukihiro Shoyama
Journal:  Pharmacognosy Res       Date:  2016 Oct-Dec

6.  Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity.

Authors:  Toshio Morikawa; Fenglin Luo; Yoshiaki Manse; Hidemi Sugita; Shunsuke Saeki; Saowanee Chaipech; Yutana Pongpiriyadacha; Osamu Muraoka; Kiyofumi Ninomiya
Journal:  Front Chem       Date:  2020-03-20       Impact factor: 5.221
  6 in total

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