OBJECTIVE: The objective of the study was to investigate temporal changes in interleukin-1 receptor antagonist (IL-1ra) in human cervicovaginal fluid (CVF) in term pregnancy and labor. STUDY DESIGN: CVF was collected weekly from 155 multiparous women from 36 weeks' gestation until labor. High vaginal swabs were collected for microbiology assessment. RESULTS: IL-1ra was decreased in spontaneous term labor, compared with 15-21 and 22-28 days from labor, and was significantly lower at 0-7 days, compared with 15-21 days before labor (P < .05, 2-way ANOVA). After subdividing the women, IL-1ra concentrations were 6-fold lower in women who had prelabor rupture of membranes at term than women who had spontaneous labor with intact membranes at 8-14 and 15-21 days before labor (P < .05, Student t test). IL-1ra concentrations were not affected by the microbial status of the vagina. CONCLUSIONS: The changes in IL-1ra concentrations observed in the CVF may be linked to the remodeling of fetal membranes leading to rupture.
OBJECTIVE: The objective of the study was to investigate temporal changes in interleukin-1 receptor antagonist (IL-1ra) in human cervicovaginal fluid (CVF) in term pregnancy and labor. STUDY DESIGN: CVF was collected weekly from 155 multiparous women from 36 weeks' gestation until labor. High vaginal swabs were collected for microbiology assessment. RESULTS:IL-1ra was decreased in spontaneous term labor, compared with 15-21 and 22-28 days from labor, and was significantly lower at 0-7 days, compared with 15-21 days before labor (P < .05, 2-way ANOVA). After subdividing the women, IL-1ra concentrations were 6-fold lower in women who had prelabor rupture of membranes at term than women who had spontaneous labor with intact membranes at 8-14 and 15-21 days before labor (P < .05, Student t test). IL-1ra concentrations were not affected by the microbial status of the vagina. CONCLUSIONS: The changes in IL-1ra concentrations observed in the CVF may be linked to the remodeling of fetal membranes leading to rupture.
Authors: Pooja Mittal; Roberto Romero; Adi L Tarca; Juan Gonzalez; Sorin Draghici; Yi Xu; Zhong Dong; Chia-Ling Nhan-Chang; Tinnakorn Chaiworapongsa; Stephen Lye; Juan Pedro Kusanovic; Leonard Lipovich; Shali Mazaki-Tovi; Sonia S Hassan; Sam Mesiano; Chong Jai Kim Journal: J Perinat Med Date: 2010-07-14 Impact factor: 1.901
Authors: Yujing Jan Heng; Stella Liong; Michael Permezel; Gregory E Rice; Megan K W Di Quinzio; Harry M Georgiou Journal: Reprod Sci Date: 2013-06-07 Impact factor: 3.060
Authors: Shannon L Gillespie; Jeremy L Neal; Lisa M Christian; Laura A Szalacha; Donna O McCarthy; Pamela J Salsberry Journal: Nurs Res Date: 2017 Mar/Apr Impact factor: 2.381
Authors: Stella Liong; Megan K W Di Quinzio; Gabrielle Fleming; Michael Permezel; Harry M Georgiou Journal: PLoS One Date: 2013-10-04 Impact factor: 3.240
Authors: Yujing J Heng; Stella Liong; Michael Permezel; Gregory E Rice; Megan K W Di Quinzio; Harry M Georgiou Journal: Front Physiol Date: 2015-05-13 Impact factor: 4.566