| Literature DB >> 186401 |
Abstract
Treatment of serum with dextransulphate polyvinylsulphate or polyanetholsulphonate resulted in a dose-dependent activation of C1 and C3; this was found for normal serum as well as for C4-deficient guinea-pig serum. Activation of C1 and C3 occurred at the same concentration of polyanions. The consumption of C3 in C4 deficient serum and the requirement of factor D of the alternative pathway indicate that C3 is activated via the alternative pathway.Entities:
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Year: 1976 PMID: 186401 PMCID: PMC1445175
Source DB: PubMed Journal: Immunology ISSN: 0019-2805 Impact factor: 7.397