| Literature DB >> 18640035 |
Chia-Lin Lee1, Kyoko Nakagawa-Goto, Donglei Yu, Yi-Nan Liu, Kenneth F Bastow, Susan L Morris-Natschke, Fang-Rong Chang, Yang-Chang Wu, Kuo-Hsiung Lee.
Abstract
Calanquinone A (1) was isolated from an EtOAc-soluble extract of Calanthe arisanensis through bioassay-guided fractionation. Its structure was identified by spectroscopic methods. Compound 1 showed potent cytotoxicity (EC(50)<0.5microg/mL) against lung (A549), prostate (PC-3 and DU145), colon (HCT-8), breast (MCF7), nasopharyngeal (KB), and vincristine-resistant nasopharyngeal (KB-VIN) cancer cell lines, and interestingly, showed an improved drug resistance profile compared to paclitaxel. The total synthesis of 1 was also achieved and is reported herein.Entities:
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Year: 2008 PMID： 18640035 PMCID： PMC2551759 DOI： 10.1016/j.bmcl.2008.06.099
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823