Literature DB >> 18639648

P53 transcriptional activities: a general overview and some thoughts.

Jean-François Millau1, Nathalie Bastien, Régen Drouin.   

Abstract

P53 is a master transcriptional regulator controlling several main cellular pathways. Its role is to adapt gene expression programs in order to maintain cellular homeostasis and genome integrity in response to stresses. P53 is found mutated in about half of human cancers and most mutations are clustered within the DNA-binding domain of the protein resulting in altered p53 transcriptional activity. This illustrates the importance of the gene regulations achieved by p53. The aim of this review is to provide a global overview of the current understanding of p53 transcriptional activities and to discuss some ongoing questions and unresolved points about p53 transcriptional activity.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18639648     DOI： 10.1016/j.mrrev.2008.06.002

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  17 in total

Review 1.  Bacterial programmed cell death: making sense of a paradox.

Authors:  Kenneth W Bayles
Journal:  Nat Rev Microbiol       Date:  2014-01       Impact factor: 60.633

2.  Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck.

Authors:  Yang Zhang; Erich M Sturgis; Zhigang Huang; Mark E Zafereo; Qingyi Wei; Guojun Li
Journal:  Cancer       Date:  2011-06-29       Impact factor: 6.860

3.  Missense and nonsense mutations of p53 gene in patients with colorectal adenocarcinoma in isfahan, central iran.

Authors:  R Golmohammadi; M J Namazi; M Nikbakht; M Salehi
Journal:  Iran Red Crescent Med J       Date:  2011-03-01       Impact factor: 0.611

4.  p53 Binds to estrogen receptor 1 promoter in human breast cancer cells.

Authors:  Mozhgan Rasti; Rita Arabsolghar; Zahed Khatooni; Zoherh Mostafavi-Pour
Journal:  Pathol Oncol Res       Date:  2011-06-08       Impact factor: 3.201

5.  Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis.

Authors:  Youn-Hee Park; Donghern Kim; Jin Dai; Zhuo Zhang
Journal:  Toxicol Appl Pharmacol       Date:  2015-06-17       Impact factor: 4.219

6.  Monodisperse double-walled microspheres loaded with chitosan-p53 nanoparticles and doxorubicin for combined gene therapy and chemotherapy.

Authors:  Qingxing Xu; Yujie Xia; Chi-Hwa Wang; Daniel W Pack
Journal:  J Control Release       Date:  2012-09-07       Impact factor: 9.776

7.  Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for treatment of human hepatocellular carcinoma.

Authors:  Qingxing Xu; Jiayu Leong; Qi Yi Chua; Yu Tse Chi; Pierce Kah-Hoe Chow; Daniel W Pack; Chi-Hwa Wang
Journal:  Biomaterials       Date:  2013-04-08       Impact factor: 12.479

8.  Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure.

Authors:  Elena V Komissarova; Toby G Rossman
Journal:  Toxicol Appl Pharmacol       Date:  2009-12-28       Impact factor: 4.219

9.  p53 Stabilization induces cell growth inhibition and affects IGF2 pathway in response to radiotherapy in adrenocortical cancer cells.

Authors:  Camilla Sampaoli; Lidia Cerquetti; Randa El Gawhary; Barbara Bucci; Donatella Amendola; Rodolfo Marchese; Silvia Misiti; Giuseppe Novelli; Vincenzo Toscano; Antonio Stigliano
Journal:  PLoS One       Date:  2012-09-19       Impact factor: 3.240

10.  Biologic variability of human foreskin fibroblasts in 2D and 3D culture: implications for a wound healing model.

Authors:  Mark A Carlson; Amy K Prall; Jeremiah J Gums; Alex Lesiak; Valerie K Shostrom
Journal:  BMC Res Notes       Date:  2009-11-18
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.