OBJECTIVE: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting RA development and progression. However, it has not been fully determined whether anti-CCP antibodies are associated with pulmonary diseases in RA patients. In the present study, we aimed to elucidate the relationships between anti-CCP antibodies and pulmonary diseases, particularly interstitial lung disease (ILD) and bronchiolitis. DESIGN AND METHODS: Using an enzyme-linked immunosorbent assay, the presence of serum anti-CCP antibodies was examined in 18 RA patients with ILD and bronchiolitis who were diagnosed based on pathologic findings. A further 36 RA subjects without any pulmonary diseases served as a reference population. RESULTS: No significant differences were found for the prevalences and levels of anti-CCP antibodies between patients with and without ILD and follicular bronchiolitis. CONCLUSION: Detection of serum anti-CCP antibodies has no association with pulmonary diseases in RA patients.
OBJECTIVE: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting RA development and progression. However, it has not been fully determined whether anti-CCP antibodies are associated with pulmonary diseases in RApatients. In the present study, we aimed to elucidate the relationships between anti-CCP antibodies and pulmonary diseases, particularly interstitial lung disease (ILD) and bronchiolitis. DESIGN AND METHODS: Using an enzyme-linked immunosorbent assay, the presence of serum anti-CCP antibodies was examined in 18 RApatients with ILD and bronchiolitis who were diagnosed based on pathologic findings. A further 36 RA subjects without any pulmonary diseases served as a reference population. RESULTS: No significant differences were found for the prevalences and levels of anti-CCP antibodies between patients with and without ILD and follicular bronchiolitis. CONCLUSION: Detection of serum anti-CCP antibodies has no association with pulmonary diseases in RApatients.
Authors: Tracy J Doyle; Avignat S Patel; Hiroto Hatabu; Mizuki Nishino; Guodong Wu; Juan C Osorio; Maria F Golzarri; Andres Traslosheros; Sarah G Chu; Michelle L Frits; Christine K Iannaccone; Diane Koontz; Carl Fuhrman; Michael E Weinblatt; Souheil Y El-Chemaly; George R Washko; Gary M Hunninghake; Augustine M K Choi; Paul F Dellaripa; Chester V Oddis; Nancy A Shadick; Dana P Ascherman; Ivan O Rosas Journal: Am J Respir Crit Care Med Date: 2015-06-15 Impact factor: 21.405
Authors: Aryeh Fischer; Joshua J Solomon; Roland M du Bois; Kevin D Deane; Amy L Olson; Evans R Fernandez-Perez; Tristan J Huie; Allen D Stevens; Mary B Gill; Avi M Rabinovitch; David A Lynch; David A Burns; Isabel S Pineiro; Steve D Groshong; Rosane D Duarte Achcar; Kevin K Brown; Richard J Martin; Jeffrey J Swigris Journal: Respir Med Date: 2012-04-12 Impact factor: 3.415
Authors: Ma de Jesús Durán-Avelar; Norberto Vibanco-Pérez; Raquel Rocío Hernández-Pacheco; América Del Carmen Castro-Zambrano; Liliana Ortiz-Martínez; José Francisco Zambrano-Zaragoza Journal: Clin Rheumatol Date: 2016-05-28 Impact factor: 2.980
Authors: José Félix Restrepo; Inmaculada del Rincón; Daniel F Battafarano; Roy W Haas; Merced Doria; Agustín Escalante Journal: Clin Rheumatol Date: 2015-08-09 Impact factor: 2.980