Literature DB >> 18637504

Functional roles of the human cytomegalovirus essential IE86 protein.

M F Stinski1, D T Petrik.   

Abstract

The IE86 protein of human cytomegalovirus (HCMV) is unique among viral and cellular proteins because it negatively autoregulates its own expression, activates the viral early and late promoters, and both activates and inhibits cellular promoters. It promotes cell cycle progression from Go/G1 to G1/S and arrests cell cycle progression at the G1/S interface or at G2/M. The IE86 protein is essential because it creates a cellular environment favorable for viral replication. The multiple functions of the IE86 protein during the replication of HCMV are reviewed.

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Year:  2008        PMID： 18637504     DOI： 10.1007/978-3-540-77349-8_8

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  53 in total

1.  Enhancerless cytomegalovirus is capable of establishing a low-level maintenance infection in severely immunodeficient host tissues but fails in exponential growth.

Authors:  Jürgen Podlech; Rares Pintea; Kai A Kropp; Annette Fink; Niels A W Lemmermann; Katja C Erlach; Elena Isern; Ana Angulo; Peter Ghazal; Matthias J Reddehase
Journal:  J Virol       Date:  2010-04-07       Impact factor: 5.103

2.  Translational control of the abundance of cytoplasmic poly(A) binding protein in human cytomegalovirus-infected cells.

Authors:  Cesar Perez; Caleb McKinney; Uyanga Chulunbaatar; Ian Mohr
Journal:  J Virol       Date:  2010-10-27       Impact factor: 5.103

3.  Phorbol ester-induced human cytomegalovirus major immediate-early (MIE) enhancer activation through PKC-delta, CREB, and NF-kappaB desilences MIE gene expression in quiescently infected human pluripotent NTera2 cells.

Authors:  Xiaoqiu Liu; Jinxiang Yuan; Allen W Wu; Patrick W McGonagill; Courtney S Galle; Jeffery L Meier
Journal:  J Virol       Date:  2010-05-26       Impact factor: 5.103

4.  The 6-Aminoquinolone WC5 inhibits different functions of the immediate-early 2 (IE2) protein of human cytomegalovirus that are essential for viral replication.

Authors:  Beatrice Mercorelli; Anna Luganini; Giulia Muratore; Serena Massari; Maria Elena Terlizzi; Oriana Tabarrini; Giorgio Gribaudo; Giorgio Palù; Arianna Loregian
Journal:  Antimicrob Agents Chemother       Date:  2014-08-25       Impact factor: 5.191

Review 5.  Chromatin-mediated regulation of cytomegalovirus gene expression.

Authors:  Matthew B Reeves
Journal:  Virus Res       Date:  2010-09-25       Impact factor: 3.303

6.  Cytomegalovirus UL91 is essential for transcription of viral true late (γ2) genes.

Authors:  Shinya Omoto; Edward S Mocarski
Journal:  J Virol       Date:  2013-05-29       Impact factor: 5.103

7.  Transcription of true late (γ2) cytomegalovirus genes requires UL92 function that is conserved among beta- and gammaherpesviruses.

Authors:  Shinya Omoto; Edward S Mocarski
Journal:  J Virol       Date:  2013-10-16       Impact factor: 5.103

8.  Human cytomegalovirus early protein pUL21a promotes efficient viral DNA synthesis and the late accumulation of immediate-early transcripts.

Authors:  Anthony R Fehr; Dong Yu
Journal:  J Virol       Date:  2010-11-03       Impact factor: 5.103

9.  Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products.

Authors:  Rebecca L Sanders; Deborah H Spector
Journal:  J Virol       Date:  2010-03-03       Impact factor: 5.103

10.  A short cis-acting motif in the M112-113 promoter region is essential for IE3 to activate M112-113 gene expression and is important for murine cytomegalovirus replication.

Authors:  Kareni J Perez; Francisco Puerta Martínez; Ruth Cosme-Cruz; Neysa M Perez-Crespo; Qiyi Tang
Journal:  J Virol       Date:  2012-12-19       Impact factor: 5.103
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