Literature DB >> 18636311

Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7.

Tomonori Nakamura1, Naoko Kodama, Yu Arai, Takuya Kumamoto, Yoshihiro Higuchi, Chaiyo Chaichantipyuth, Tsutomu Ishikawa, Koichi Ueno, Shingo Yano.   

Abstract

In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages. Isolation of active oxycoumarins was guided by Western blot analysis of iNOS protein expression. These oxycoumarins showed an inhibitory effect on iNOS protein expression at 10 microM. Further examination of the inhibitory effects of these compounds on inflammation mediators revealed that the synthesis of nitric oxide (NO) and the protein expression of tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) were inhibited by 5. It was expected that these compounds show anti-inflammatory activities.

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Year:  2008        PMID： 18636311     DOI： 10.1007/s11418-008-0277-5

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  21 in total

1.  Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.

Authors:  Arunrat Sunthitikawinsakul; Ngampong Kongkathip; Boonsong Kongkathip; Sida Phonnakhu; John W Daly; Thomas F Spande; Yuth Nimit; Sasarose Rochanaruangrai
Journal:  Planta Med       Date:  2003-02       Impact factor: 3.352

2.  Effect of curcumin on the production of nitric oxide by cultured rat mammary gland.

Authors:  M Onoda; H Inano
Journal:  Nitric Oxide       Date:  2000-10       Impact factor: 4.427

3.  Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity.

Authors:  Saibal K Biswas; Danny McClure; Luis A Jimenez; Ian L Megson; Irfan Rahman
Journal:  Antioxid Redox Signal       Date:  2005 Jan-Feb       Impact factor: 8.401

4.  Nitric oxide and peroxynitrite released by ultraviolet B-irradiated human endothelial cells are possibly involved in skin erythema and inflammation.

Authors:  G Deliconstantinos; V Villiotou; J C Stavrides
Journal:  Exp Physiol       Date:  1996-11       Impact factor: 2.969

5.  Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells.

Authors:  A Murakami; G Gao; O K Kim; M Omura; M Yano; C Ito; H Furukawa; S Jiwajinda; K Koshimizu; H Ohigashi
Journal:  J Agric Food Chem       Date:  1999-01       Impact factor: 5.279

6.  Cytotoxic coumarins and lignans from extracts of the northern prickly ash (Zanthoxylum americanum).

Authors:  Y Ju; C C Still; J N Sacalis; J Li; C T Ho
Journal:  Phytother Res       Date:  2001-08       Impact factor: 5.878

7.  The role of Src kinase in the potentiation by ethanol of cytokine- and endotoxin-mediated nitric oxide synthase expression in rat hepatocytes.

Authors:  M L Kuo; Y P Chau; J H Wang; P J Lin
Journal:  Mol Pharmacol       Date:  1997-09       Impact factor: 4.436

8.  Preparative isolation of osthol and xanthotoxol from Common Cnidium Fruit (Chinese traditional herb) using stepwise elution by high-speed counter-current chromatography.

Authors:  Yun Wei; Tianyou Zhang; Yoichiro Ito
Journal:  J Chromatogr A       Date:  2004-04-16       Impact factor: 4.759

9.  A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression.

Authors:  Akihiro Hosokawa; Megumi Sumino; Tomonori Nakamura; Shingo Yano; Toshikazu Sekine; Nijsiri Ruangrungsi; Kazuko Watanabe; Fumio Ikegami
Journal:  Chem Pharm Bull (Tokyo)       Date:  2004-10       Impact factor: 1.645

10.  A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes.

Authors:  D Bruch-Gerharz; K Fehsel; C Suschek; G Michel; T Ruzicka; V Kolb-Bachofen
Journal:  J Exp Med       Date:  1996-11-01       Impact factor: 14.307
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  18 in total

1.  Neuroprotective Effect of Osthole on Neuron Synapses in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9.

Authors:  Shaoheng Li; Yuhui Yan; Yanan Jiao; Zhong Gao; Yang Xia; Liang Kong; Yingjia Yao; Zhenyu Tao; Jie Song; Yaping Yan; Guangxian Zhang; Jingxian Yang
Journal:  J Mol Neurosci       Date:  2016-07-09       Impact factor: 3.444

2.  Osthole, a natural coumarin improves cognitive impairments and BBB dysfunction after transient global brain ischemia in C57 BL/6J mice: involvement of Nrf2 pathway.

Authors:  ZiWei Chen; XueXuan Mao; AnMin Liu; XiaoYun Gao; XiaoHong Chen; MinZhong Ye; JianTao Ye; PeiQing Liu; SuoWen Xu; JianXin Liu; Wei He; QiShen Lian; RongBiao Pi
Journal:  Neurochem Res       Date:  2014-11-26       Impact factor: 3.996

3.  Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion.

Authors:  Qiu-Lan He; Yuling Chen; Jian Qin; Sui-Lin Mo; Ming Wei; Jin-Jun Zhang; Mei-Na Li; Xue-Nong Zou; Shu-Feng Zhou; Xiao-Wu Chen; Lai-Bao Sun
Journal:  Med Sci Monit       Date:  2012-06

4.  Primary human monocyte differentiation regulated by Nigella sativa pressed oil.

Authors:  Mahaya C Mat; Azman S Mohamed; Shahrul S Hamid
Journal:  Lipids Health Dis       Date:  2011-11-21       Impact factor: 3.876

5.  Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma.

Authors:  Lurong Zhang; Guorong Jiang; Fei Yao; Yan He; Guoqiang Liang; Yinsheng Zhang; Bo Hu; Yan Wu; Yunsen Li; Haiyan Liu
Journal:  PLoS One       Date:  2012-05-25       Impact factor: 3.240

6.  Evaluation of Antioxidant Activity and Acute Toxicity of Clausena excavata Leaves Extract.

Authors:  Shaymaa Fadhel Abbas Albaayit; Yusuf Abba; Rasedee Abdullah; Noorlidah Abdullah
Journal:  Evid Based Complement Alternat Med       Date:  2014-12-24       Impact factor: 2.629

7.  Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition.

Authors:  Ismail Adam Arbab; Chung Yeng Looi; Ahmad Bustamam Abdul; Foo Kit Cheah; Won Fen Wong; Mohd Aspollah Sukari; Rasedee Abdullah; Syam Mohan; Suvitha Syam; Aditya Arya; Manal Mohamed Elhassan Taha; Bushra Muharram; Mohd Rais Mustafa; Siddig Ibrahim Abdelwahab
Journal:  Evid Based Complement Alternat Med       Date:  2012-10-03       Impact factor: 2.629

Review 8.  Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine.

Authors:  Zhong-Rong Zhang; Wing Nang Leung; Ho Yee Cheung; Chun Wai Chan
Journal:  Evid Based Complement Alternat Med       Date:  2015-07-13       Impact factor: 2.629

9.  Synthesis and characterization of low-toxicity N-caprinoyl-N-trimethyl chitosan as self-assembled micelles carriers for osthole.

Authors:  Xiao-juan Hu; Yang Liu; Xiao-feng Zhou; Qiao-ling Zhu; Yong-yan Bei; Ben-gang You; Chun-ge Zhang; Wei-liang Chen; Zhou-li Wang; Ai-jun Zhu; Xue-nong Zhang; Yu-jiang Fan
Journal:  Int J Nanomedicine       Date:  2013-09-20

10.  N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein for targeted osthole-loaded delivery to low-density lipoprotein receptor-rich tumors.

Authors:  Chun-ge Zhang; Qiao-ling Zhu; Yi Zhou; Yang Liu; Wei-liang Chen; Zhi-Qiang Yuan; Shu-di Yang; Xiao-feng Zhou; Ai-jun Zhu; Xue-nong Zhang; Yong Jin
Journal:  Int J Nanomedicine       Date:  2014-06-13
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