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Literature DB >> 18636236

Molecular characterization of Pegarn: a Drosophila homolog of UNC-51 kinase.

A Ahantarig¹, L V Chadwell, I B Terrazas, C T Garcia, J J Nazarian, H K Lee, M J Lundell, J A Cassill.

Abstract

We have isolated and characterized the gene encoding a Drosophila melanogaster homolog of Caenorhabditis elegans UNC-51 (uncoordinated movement-51): Pegarn. Developmental Northern blot shows the Pegarn gene is expressed at all stages of development. The protein is detected throughout the Drosophila third instar larval central nervous system (CNS) in axons projecting out from the ventral ganglion and in the optic anlagen of the optic lobe. Heterozygous Pegarn mutant embryos show defects in larval axonal neuronal patterning, but survive to adulthood. Homozygous mutants have an even more deformed pattern of neuronal development and do not survive through the larval stages. The data from this research suggest the critical roles of Pegarn in CNS and PNS axonal formation in Drosophila melanogaster and indicates its similar role in other multicellular species.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18636236 PMCID： PMC2946226 DOI： 10.1007/s11033-008-9314-4

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

28 in total

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4. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

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Journal: Oncogene Date: 1999-10-21 Impact factor: 9.867

6. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.

Authors: N Okazaki; J Yan; S Yuasa; T Ueno; E Kominami; Y Masuho; H Koga; M Muramatsu
Journal: Brain Res Mol Brain Res Date: 2000-12-28

7. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.

Authors: Xiang Zhou; J Ramesh Babu; Susana da Silva; Qing Shu; Isabella A Graef; Tim Oliver; Toshifumi Tomoda; Tomomi Tani; Marie W Wooten; Fan Wang
Journal: Proc Natl Acad Sci U S A Date: 2007-03-26 Impact factor: 11.205

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Authors: S Brenner
Journal: Genetics Date: 1974-05 Impact factor: 4.562

9. Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

Authors: S K Hanks
Journal: Proc Natl Acad Sci U S A Date: 1987-01 Impact factor: 11.205

10. The genome sequence of Drosophila melanogaster.

Authors: M D Adams; S E Celniker; R A Holt; C A Evans; J D Gocayne; P G Amanatides; S E Scherer; P W Li; R A Hoskins; R F Galle; R A George; S E Lewis; S Richards; M Ashburner; S N Henderson; G G Sutton; J R Wortman; M D Yandell; Q Zhang; L X Chen; R C Brandon; Y H Rogers; R G Blazej; M Champe; B D Pfeiffer; K H Wan; C Doyle; E G Baxter; G Helt; C R Nelson; G L Gabor; J F Abril; A Agbayani; H J An; C Andrews-Pfannkoch; D Baldwin; R M Ballew; A Basu; J Baxendale; L Bayraktaroglu; E M Beasley; K Y Beeson; P V Benos; B P Berman; D Bhandari; S Bolshakov; D Borkova; M R Botchan; J Bouck; P Brokstein; P Brottier; K C Burtis; D A Busam; H Butler; E Cadieu; A Center; I Chandra; J M Cherry; S Cawley; C Dahlke; L B Davenport; P Davies; B de Pablos; A Delcher; Z Deng; A D Mays; I Dew; S M Dietz; K Dodson; L E Doup; M Downes; S Dugan-Rocha; B C Dunkov; P Dunn; K J Durbin; C C Evangelista; C Ferraz; S Ferriera; W Fleischmann; C Fosler; A E Gabrielian; N S Garg; W M Gelbart; K Glasser; A Glodek; F Gong; J H Gorrell; Z Gu; P Guan; M Harris; N L Harris; D Harvey; T J Heiman; J R Hernandez; J Houck; D Hostin; K A Houston; T J Howland; M H Wei; C Ibegwam; M Jalali; F Kalush; G H Karpen; Z Ke; J A Kennison; K A Ketchum; B E Kimmel; C D Kodira; C Kraft; S Kravitz; D Kulp; Z Lai; P Lasko; Y Lei; A A Levitsky; J Li; Z Li; Y Liang; X Lin; X Liu; B Mattei; T C McIntosh; M P McLeod; D McPherson; G Merkulov; N V Milshina; C Mobarry; J Morris; A Moshrefi; S M Mount; M Moy; B Murphy; L Murphy; D M Muzny; D L Nelson; D R Nelson; K A Nelson; K Nixon; D R Nusskern; J M Pacleb; M Palazzolo; G S Pittman; S Pan; J Pollard; V Puri; M G Reese; K Reinert; K Remington; R D Saunders; F Scheeler; H Shen; B C Shue; I Sidén-Kiamos; M Simpson; M P Skupski; T Smith; E Spier; A C Spradling; M Stapleton; R Strong; E Sun; R Svirskas; C Tector; R Turner; E Venter; A H Wang; X Wang; Z Y Wang; D A Wassarman; G M Weinstock; J Weissenbach; S M Williams; K C Worley; D Wu; S Yang; Q A Yao; J Ye; R F Yeh; J S Zaveri; M Zhan; G Zhang; Q Zhao; L Zheng; X H Zheng; F N Zhong; W Zhong; X Zhou; S Zhu; X Zhu; H O Smith; R A Gibbs; E W Myers; G M Rubin; J C Venter
Journal: Science Date: 2000-03-24 Impact factor: 47.728

8 in total

1. Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans.

Authors: Ken-ichi Ogura; Takako Okada; Shohei Mitani; Keiko Gengyo-Ando; David L Baillie; Yuji Kohara; Yoshio Goshima
Journal: Development Date: 2010-04-14 Impact factor: 6.868

Molecular characterization of Pegarn: a Drosophila homolog of UNC-51 kinase.

Review 1. Signaling--2000 and beyond.

Review 2. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

3. Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes.

4. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

5. Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains.

6. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.

7. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.

8. The genetics of Caenorhabditis elegans.

9. Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

10. The genome sequence of Drosophila melanogaster.

1. Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans.

2. Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis.

3. Unc-51 controls active zone density and protein composition by downregulating ERK signaling.

4. UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly.

5. Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging.

6. Atg13 Is Essential for Autophagy and Cardiac Development in Mice.

Review 7. Autophagy-monitoring and autophagy-deficient mice.

8. Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation.