Literature DB >> 18636205

Analysis of the methylation status of genes up-regulated by the demethylating agent, 5-aza-2'-deoxycytidine, in esophageal squamous cell carcinoma.

Makoto Arai1, Fumio Imazeki, Yuzo Sakai, Rintaro Mikata, Motohisa Tada, Naohiko Seki, Hideaki Shimada, Takenori Ochiai, Osamu Yokosuka.   

Abstract

To determine the clinical significance of gene promoter methylation in esophageal squamous cell carcinoma (ESCC), we examined the promoter methylation status of genes showing elevated expression, as determined by DNA microarray-based transcriptomic analysis, in three ESCC cell lines (TE-1, TE-2, TE-10) after 5-aza-2'-deoxycytidine (DAC) treatment. We observed a high degree of DNA methylation within the promoter regions of three genes, namely cathepsin L2 (CTSL2), normal mucosa of esophagus specific 1 (NMES1), and fatty acid binding protein 5 (FABP5). Overexpression of NMES1 in ESCC cell lines increased cell motility. Down-regulation of NMES1 might play an important role in the cell motility of ESCC or be a potent marker of malignancy.

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Year:  2008        PMID： 18636205

Source DB:  PubMed          Journal:  Oncol Rep        ISSN： 1021-335X            Impact factor:   3.906


  10 in total

1.  l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.

Authors:  Yi-Ping Leng; Ye-Shuo Ma; Xiao-Gang Li; Rui-Fang Chen; Ping-Yu Zeng; Xiao-Hui Li; Cheng-Feng Qiu; Ya-Pei Li; Zhen Zhang; Alex F Chen
Journal:  Br J Pharmacol       Date:  2017-08-11       Impact factor: 8.739

2.  Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine.

Authors:  Theresa D Ahrens; Sylvia Timme; Jens Hoeppner; Jenny Ostendorp; Sina Hembach; Marie Follo; Ulrich T Hopt; Martin Werner; Hauke Busch; Melanie Boerries; Silke Lassmann
Journal:  Epigenetics       Date:  2015       Impact factor: 4.528

3.  Treatment with demethylating agent, 5-aza-2'-deoxycytidine enhances therapeutic HPV DNA vaccine potency.

Authors:  Dan Lu; Talia Hoory; Archana Monie; Annie Wu; Mei-Cheng Wang; Chien-Fu Hung
Journal:  Vaccine       Date:  2009-02-24       Impact factor: 3.641

Review 4.  Therapeutic HPV DNA vaccines.

Authors:  Ken Lin; Elena Roosinovich; Barbara Ma; Chien-Fu Hung; T-C Wu
Journal:  Immunol Res       Date:  2010-07       Impact factor: 2.829

Review 5.  Therapeutic HPV DNA vaccines.

Authors:  Archana Monie; Shaw-Wei D Tsen; Chien-Fu Hung; T-C Wu
Journal:  Expert Rev Vaccines       Date:  2009-09       Impact factor: 5.217

6.  A systematic analysis of human lipocalin family and its expression in esophageal carcinoma.

Authors:  Ze-Peng Du; Bing-Li Wu; Xuan Wu; Xuan-Hao Lin; Xiao-Yang Qiu; Xiao-Fen Zhan; Shao-Hong Wang; Jin-Hui Shen; Chun-Peng Zheng; Zhi-Yong Wu; Li-Yan Xu; Dong Wang; En-Min Li
Journal:  Sci Rep       Date:  2015-07-01       Impact factor: 4.379

7.  Effect on Multipotency and Phenotypic Transition of Unrestricted Somatic Stem Cells from Human Umbilical Cord Blood after Treatment with Epigenetic Agents.

Authors:  Foued Ghanjati; Simeon Santourlidis
Journal:  Stem Cells Int       Date:  2015-12-14       Impact factor: 5.443

8.  Altered epidermal fatty acid-binding protein expression in hepatocellular carcinoma predicts unfavorable outcomes.

Authors:  Jia-Bin Lu; Shao-Hang Cai; Ying-Hua Pan; Jing-Ping Yun
Journal:  Cancer Manag Res       Date:  2018-11-23       Impact factor: 3.989

9.  IBDsite: a Galaxy-interacting, integrative database for supporting inflammatory bowel disease high throughput data analysis.

Authors:  I Merelli; F Viti; L Milanesi
Journal:  BMC Bioinformatics       Date:  2012-09-07       Impact factor: 3.169

10.  Hypermethylation of normal mucosa of esophagus-specific 1 is associated with an unfavorable prognosis in patients with non-small cell lung cancer.

Authors:  Dong Sun Kim; Won Kee Lee; Jae Yong Park
Journal:  Oncol Lett       Date:  2018-06-06       Impact factor: 2.967
  10 in total

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