Literature DB >> 18635000

Bivalent aptamers deliver the punch.

Jiehua Zhou1, John J Rossi.   

Abstract

Aptamers, sometimes termed "chemical antibodies," have been engineered into multimerized versions for therapeutic application. The groups of Gilboa and Sullenger now report the development of a bivalent aptamer-molecular device as a receptor agonist that has the same functional properties, but stronger avidity than a corresponding antibody.

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Year:  2008        PMID: 18635000     DOI: 10.1016/j.chembiol.2008.07.004

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  7 in total

1.  DNA aptamers that target human glioblastoma multiforme cells overexpressing epidermal growth factor receptor variant III in vitro.

Authors:  Yan Tan; Yu-sheng Shi; Xi-dong Wu; Hui-yu Liang; Yu-bo Gao; Shu-ji Li; Xing-mei Zhang; Fang Wang; Tian-ming Gao
Journal:  Acta Pharmacol Sin       Date:  2013-12       Impact factor: 6.150

2.  Nucleic Acid Aptamers as Potential Therapeutic and Diagnostic Agents for Lymphoma.

Authors:  Ka-To Shum; Jiehua Zhou; John J Rossi
Journal:  J Cancer Ther       Date:  2013-06-01

Review 3.  Aptamers as therapeutics.

Authors:  Anthony D Keefe; Supriya Pai; Andrew Ellington
Journal:  Nat Rev Drug Discov       Date:  2010-07       Impact factor: 84.694

Review 4.  New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer.

Authors:  Zi-Ting Yao; Yan-Ming Yang; Miao-Miao Sun; Yan He; Long Liao; Kui-Sheng Chen; Bin Li
Journal:  Cancer Commun (Lond)       Date:  2022-01-12

5.  Comparison of the 'chemical' and 'structural' approaches to the optimization of the thrombin-binding aptamer.

Authors:  Olga Tatarinova; Vladimir Tsvetkov; Dmitry Basmanov; Nikolay Barinov; Igor Smirnov; Edward Timofeev; Dmitry Kaluzhny; Andrey Chuvilin; Dmitry Klinov; Anna Varizhuk; Galina Pozmogova
Journal:  PLoS One       Date:  2014-02-20       Impact factor: 3.240

6.  Aptamer-based therapeutics: new approaches to combat human viral diseases.

Authors:  Ka-To Shum; Jiehua Zhou; John J Rossi
Journal:  Pharmaceuticals (Basel)       Date:  2013-11-25

Review 7.  Engineered Aptamers to Probe Molecular Interactions on the Cell Surface.

Authors:  Sana Batool; Sanam Bhandari; Shanell George; Precious Okeoma; Nabeela Van; Hazan E Zümrüt; Prabodhika Mallikaratchy
Journal:  Biomedicines       Date:  2017-08-29
  7 in total

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