Literature DB >> 18633951

8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.

Marjolein J Vliem1, Bas Ponsioen, Frank Schwede, Willem-Jan Pannekoek, Jurgen Riedl, Matthijs R H Kooistra, Kees Jalink, Hans-Gottfried Genieser, Johannes L Bos, Holger Rehmann.   

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Year:  2008        PMID： 18633951     DOI： 10.1002/cbic.200800216

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  68 in total

1.  cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane.

Authors:  Sarah V Consonni; Martijn Gloerich; Emma Spanjaard; Johannes L Bos
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-16       Impact factor: 11.205

2.  Facilitation of ß-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac.

Authors:  Colin A Leech; Igor Dzhura; Oleg G Chepurny; Frank Schwede; Hans-G Genieser; George G Holz
Journal:  Islets       Date:  2010 Mar-Apr       Impact factor: 2.694

3.  Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure.

Authors:  Geurt Stokman; Yu Qin; Hans-Gottfried Genieser; Frank Schwede; Emile de Heer; Johannes L Bos; Ingeborg M Bajema; Bob van de Water; Leo S Price
Journal:  J Am Soc Nephrol       Date:  2011-04-14       Impact factor: 10.121

4.  Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.

Authors:  Grant G Kelley; Oleg G Chepurny; Frank Schwede; Hans-G Genieser; Colin A Leech; Michael W Roe; Xiangquan Li; Igor Dzhura; Elvira Dzhura; Parisa Afshari; George G Holz
Journal:  Islets       Date:  2009 Nov-Dec       Impact factor: 2.694

5.  Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

Authors:  Igor Dzhura; Oleg G Chepurny; Grant G Kelley; Colin A Leech; Michael W Roe; Elvira Dzhura; Parisa Afshari; Sundeep Malik; Michael J Rindler; Xin Xu; Youming Lu; Alan V Smrcka; George G Holz
Journal:  J Physiol       Date:  2010-11-01       Impact factor: 5.182

6.  Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.

Authors:  Na Ye; Yingmin Zhu; Haijun Chen; Zhiqing Liu; Fang C Mei; Christopher Wild; Haiying Chen; Xiaodong Cheng; Jia Zhou
Journal:  J Med Chem       Date:  2015-07-16       Impact factor: 7.446

7.  Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity.

Authors:  Shekher Mohan; Shuh Narumiya; Sylvain Doré
Journal:  Neurotoxicology       Date:  2014-11-13       Impact factor: 4.294

8.  EPAC1 regulates endothelial annexin A2 cell surface translocation and plasminogen activation.

Authors:  Wenli Yang; Fang C Mei; Xiaodong Cheng
Journal:  FASEB J       Date:  2018-01-05       Impact factor: 5.191

9.  PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

Authors:  Oleg G Chepurny; Grant G Kelley; Igor Dzhura; Colin A Leech; Michael W Roe; Elvira Dzhura; Xiangquan Li; Frank Schwede; Hans-G Genieser; George G Holz
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-12-15       Impact factor: 4.310

10.  A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.

Authors:  Muayad Almahariq; Tamara Tsalkova; Fang C Mei; Haijun Chen; Jia Zhou; Sarita K Sastry; Frank Schwede; Xiaodong Cheng
Journal:  Mol Pharmacol       Date:  2012-10-11       Impact factor: 4.436
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