Literature DB >> 18633586

[Pharmacotherapy of central oculomotor disorders].

R Kalla1, R Spiegel, J Wagner, N Rettinger, K Jahn, M Strupp.   

Abstract

Nystagmus causes blurred vision due to oscillopsia, as well as impaired balance. Depending on etiology, additional cerebellar and brain stem signs may occur. We present the current pharmacotherapy of the most common forms of central nystagmus: downbeat nystagmus (DBN), upbeat nystagmus (UBN), acquired pendular nystagmus (APN), and congenital nystagmus (CGN). Recommended medical therapies are aminopyridines (4-AP) for DBN and UBN, gabapentin and memantine for CGN and APN, and baclofen for periodic alternating nystagmus (PAN).

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Year:  2008        PMID: 18633586     DOI: 10.1007/s00115-008-2516-0

Source DB:  PubMed          Journal:  Nervenarzt        ISSN: 0028-2804            Impact factor:   1.214


  24 in total

1.  Effect of 3,4-diaminopyridine on the gravity dependence of ocular drift in downbeat nystagmus.

Authors:  C Helmchen; A Sprenger; H Rambold; T Sander; D Kömpf; D Straumann
Journal:  Neurology       Date:  2004-08-24       Impact factor: 9.910

2.  4-aminopyridine improves downbeat nystagmus, smooth pursuit, and VOR gain.

Authors:  R Kalla; S Glasauer; F Schautzer; N Lehnen; U Büttner; M Strupp; T Brandt
Journal:  Neurology       Date:  2004-04-13       Impact factor: 9.910

3.  18F-fluorodeoxyglucose hypometabolism in cerebellar tonsil and flocculus in downbeat nystagmus.

Authors:  Sandra Bense; Christoph Best; Hans-Georg Buchholz; Valerie Wiener; Mathias Schreckenberger; Peter Bartenstein; Marianne Dieterich
Journal:  Neuroreport       Date:  2006-04-24       Impact factor: 1.837

4.  Detection of floccular hypometabolism in downbeat nystagmus by fMRI.

Authors:  R Kalla; A Deutschlander; K Hufner; T Stephan; K Jahn; S Glasauer; T Brandt; M Strupp
Journal:  Neurology       Date:  2006-01-24       Impact factor: 9.910

5.  Effects of ablation of flocculus and paraflocculus of eye movements in primate.

Authors:  D S Zee; A Yamazaki; P H Butler; G Gücer
Journal:  J Neurophysiol       Date:  1981-10       Impact factor: 2.714

6.  Role of clonazepam in the treatment of idiopathic downbeat nystagmus.

Authors:  Y H Young; T W Huang
Journal:  Laryngoscope       Date:  2001-08       Impact factor: 3.325

7.  Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells.

Authors:  Y Etzion; Y Grossman
Journal:  Exp Brain Res       Date:  2001-08       Impact factor: 1.972

8.  The use of clonazepam in the treatment of nystagmus-induced oscillopsia.

Authors:  J N Currie; V Matsuo
Journal:  Ophthalmology       Date:  1986-07       Impact factor: 12.079

9.  Treatment of periodic alternating nystagmus.

Authors:  G M Halmagyi; P Rudge; M A Gresty; R J Leigh; D S Zee
Journal:  Ann Neurol       Date:  1980-12       Impact factor: 10.422

10.  Three-dimensional eye position and slow phase velocity in humans with downbeat nystagmus.

Authors:  S Glasauer; M Hoshi; U Kempermann; T Eggert; U Büttner
Journal:  J Neurophysiol       Date:  2003-01       Impact factor: 2.714

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  1 in total

1.  Summary of eye examinations of 284 patients with multiple sclerosis.

Authors:  Jan M Roodhooft
Journal:  Int J MS Care       Date:  2012
  1 in total

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