Literature DB >> 18633519

The tert-butyl group in chemistry and biology.

Philippe Bisel1, Loay Al-Momani, Michael Müller.   

Abstract

The unique reactivity pattern elicited by the crowded tert-butyl group is highlighted by summarising characteristic applications. Starting from the use of this simple hydrocarbon moiety in chemical transformations, via its relevance in Nature and its implication in biosynthetic and biodegradation pathways, the way through to its possible application in biocatalytic processes is described.

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Year:  2008        PMID： 18633519     DOI： 10.1039/b800083b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  11 in total

1.  Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module.

Authors:  Meredith A Skiba; Andrew P Sikkema; Nathan A Moss; Andrew N Lowell; Min Su; Rebecca M Sturgis; Lena Gerwick; William H Gerwick; David H Sherman; Janet L Smith
Journal:  ACS Chem Biol       Date:  2018-05-08       Impact factor: 5.100

2.  Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme.

Authors:  Yuanyou Wang; Bastien Schnell; Sascha Baumann; Rolf Müller; Tadhg P Begley
Journal:  J Am Chem Soc       Date:  2017-01-25       Impact factor: 15.419

3.  Proline editing: a general and practical approach to the synthesis of functionally and structurally diverse peptides. Analysis of steric versus stereoelectronic effects of 4-substituted prolines on conformation within peptides.

Authors:  Anil K Pandey; Devan Naduthambi; Krista M Thomas; Neal J Zondlo
Journal:  J Am Chem Soc       Date:  2013-03-11       Impact factor: 15.419

4.  Catalytic Enantioselective Synthesis of Difluorinated Alkyl Bromides.

Authors:  Mark D Levin; John M Ovian; Jacquelyne A Read; Matthew S Sigman; Eric N Jacobsen
Journal:  J Am Chem Soc       Date:  2020-08-24       Impact factor: 15.419

5.  TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling.

Authors:  Alan R Wolfe; R Jeffrey Neitz; Mark Burlingame; Brian M Suzuki; K C Lim; Mark Scheideler; David L Nelson; Leslie Z Benet; Conor R Caffrey
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2018-11-20       Impact factor: 4.077

6.  Sterically Hindered Quaternary Phosphonium Salts (QPSs): Antimicrobial Activity and Hemolytic and Cytotoxic Properties.

Authors:  Vadim V Ermolaev; Daria M Arkhipova; Vasili A Miluykov; Anna P Lyubina; Syumbelya K Amerhanova; Natalia V Kulik; Alexandra D Voloshina; Valentine P Ananikov
Journal:  Int J Mol Sci       Date:  2021-12-22       Impact factor: 5.923

Review 7.  In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism.

Authors:  Valery M Dembitsky
Journal:  Mar Drugs       Date:  2021-11-22       Impact factor: 5.118

8.  (2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline: two conformationally distinct proline amino acids for sensitive application in 19F NMR.

Authors:  Caitlin M Tressler; Neal J Zondlo
Journal:  J Org Chem       Date:  2014-06-06       Impact factor: 4.354

9.  tert-Butylphenolic Derivatives from Paenibacillus odorifer-A Case of Bioconversion.

Authors:  Thi-Bach-Le Nguyen; Olivier Delalande; Isabelle Rouaud; Solenn Ferron; Laura Chaillot; Rémy Pedeux; Sophie Tomasi
Journal:  Molecules       Date:  2018-08-05       Impact factor: 4.411

10.  Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.

Authors:  Hiran A Prag; Laura Pala; Duvaraka Kula-Alwar; John F Mulvey; Du Luping; Timothy E Beach; Lee M Booty; Andrew R Hall; Angela Logan; Volha Sauchanka; Stuart T Caldwell; Ellen L Robb; Andrew M James; Zhelong Xu; Kourosh Saeb-Parsy; Richard C Hartley; Michael P Murphy; Thomas Krieg
Journal:  Cardiovasc Drugs Ther       Date:  2020-07-09       Impact factor: 3.727
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