Literature DB >> 18633517

Synthesis and characterization of a smart contrast agent sensitive to calcium.

Kirti Dhingra1, Martin E Maier, Michael Beyerlein, Goran Angelovski, Nikos K Logothetis.   

Abstract

A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows approximately 100% relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements.

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Year:  2008        PMID： 18633517     DOI： 10.1039/b801975d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

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Review 2.  Smart MR imaging agents relevant to potential neurologic applications.

Authors:  C S Bonnet; E Tóth
Journal:  AJNR Am J Neuroradiol       Date:  2009-10-15       Impact factor: 3.825

Review 3.  A review of responsive MRI contrast agents: 2005-2014.

Authors:  Dina V Hingorani; Adam S Bernstein; Mark D Pagel
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4.  A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA-tetraglycinate.

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Journal:  NMR Biomed       Date:  2011-12       Impact factor: 4.044

Review 5.  Molecular fMRI of neurochemical signaling.

Authors:  He Wei; Abigail M Frey; Alan Jasanoff
Journal:  J Neurosci Methods       Date:  2021-09-29       Impact factor: 2.390

Review 6.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
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Review 7.  Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.

Authors:  Shenghui Xue; Jingjuan Qiao; Fan Pu; Mathew Cameron; Jenny J Yang
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2013-01-17

Review 8.  Calcium-responsive contrast agents for functional magnetic resonance imaging.

Authors:  Austin D C Miller; Harun F Ozbakir; Arnab Mukherjee
Journal:  Chem Phys Rev       Date:  2021-06

9.  Photoreversible stretching of a BAPTA chelator marshalling Ca2+-binding in aqueous media.

Authors:  Aurélien Ducrot; Arnaud Tron; Robin Bofinger; Ingrid Sanz Beguer; Jean-Luc Pozzo; Nathan D McClenaghan
Journal:  Beilstein J Org Chem       Date:  2019-11-21       Impact factor: 2.883
  9 in total

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