Literature DB >> 18633486

Binding of a dinuclear ruthenium(ii) complex to the TAR region of the HIV-AIDS viral RNA.

Damian P Buck1, Caitriona B Spillane, J Grant Collins, F Richard Keene.   

Abstract

Molecular modelling has identified a new RNA conformational feature created by the insertion of bulge residues into duplex regions that may act as a recognition site for small molecule binding, in particular for inert dinuclear ruthenium complexes.

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Year:  2008        PMID: 18633486     DOI: 10.1039/b803216e

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN: 1742-2051


  3 in total

1.  Effects of chirality on the intracellular localization of binuclear ruthenium(II) polypyridyl complexes.

Authors:  Frida R Svensson; Johanna Andersson; Helene L Åmand; Per Lincoln
Journal:  J Biol Inorg Chem       Date:  2012-02-05       Impact factor: 3.358

2.  Iron(II) supramolecular helicates interfere with the HIV-1 Tat-TAR RNA interaction critical for viral replication.

Authors:  Jaroslav Malina; Michael J Hannon; Viktor Brabec
Journal:  Sci Rep       Date:  2016-07-12       Impact factor: 4.379

3.  Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo.

Authors:  Lucia Cardo; Isabel Nawroth; Peter J Cail; Jane A McKeating; Michael J Hannon
Journal:  Sci Rep       Date:  2018-09-06       Impact factor: 4.379

  3 in total

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