Literature DB >> 18632625

PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma.

Yu-Jen Chen1, Hamish G Campbell, Anna K Wiles, Michael R Eccles, Roger R Reddel, Antony W Braithwaite, Janice A Royds.   

Abstract

Paired box (PAX) developmental genes are frequently expressed in cancers and confer survival advantages on cancer cells. We have previously found that PAX genes are deregulated in glioma. We have now investigated the expression of PAX genes in glioma and their role in telomere maintenance. The mRNA level of PAX8 showed a positive correlation with telomerase activity in glioma biopsies (r(2) = 0.75, P < 0.001) and in established glioma cell lines (r(2) = 0.97, P = 0.0025). We found that PAX8 is able to coordinately transactivate the promoter for both the telomerase catalytic subunit (hTERT) and the telomerase RNA component (hTR) genes. By electrophoretic mobility shift assay, quantitative PCR, and a telomerase activity assay, we show that PAX8 binds directly to the hTERT and hTR promoters, up-regulating hTERT and hTR mRNA, as well as telomerase activity. Additionally, PAX8 small interfering RNA down-regulated hTERT and hTR. Collectively, these results show that PAX8 may have a role in telomerase regulation.

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Year:  2008        PMID： 18632625     DOI： 10.1158/0008-5472.CAN-08-0058

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  20 in total

Review 1.  TERRA Gene Expression in Gastric Cancer: Role of hTERT.

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Journal:  J Gastrointest Cancer       Date:  2021-01-07

2.  PAX5 activates the transcription of the human telomerase reverse transcriptase gene in B cells.

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Journal:  J Pathol       Date:  2010-01       Impact factor: 7.996

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Authors:  Noelyn A Hung; Ramona A Eiholzer; Stenar Kirs; Jean Zhou; Kirsten Ward-Hartstonge; Anna K Wiles; Chris M Frampton; Ahmad Taha; Janice A Royds; Tania L Slatter
Journal:  Mod Pathol       Date:  2016-01-15       Impact factor: 7.842

4.  Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.

Authors:  Jonathan Beesley; Hilda A Pickett; Sharon E Johnatty; Alison M Dunning; Xiaoqing Chen; Jun Li; Kyriaki Michailidou; Yi Lu; David N Rider; Rachel T Palmieri; Michael D Stutz; Diether Lambrechts; Evelyn Despierre; Sandrina Lambrechts; Ignace Vergote; Jenny Chang-Claude; Stefan Nickels; Alina Vrieling; Dieter Flesch-Janys; Shan Wang-Gohrke; Ursula Eilber; Natalia Bogdanova; Natalia Antonenkova; Ingo B Runnebaum; Thilo Dörk; Marc T Goodman; Galina Lurie; Lynne R Wilkens; Rayna K Matsuno; Lambertus A Kiemeney; Katja K H Aben; Tamara Marees; Leon F A G Massuger; Brooke L Fridley; Robert A Vierkant; Elisa V Bandera; Sara H Olson; Irene Orlow; Lorna Rodriguez-Rodriguez; Linda S Cook; Nhu D Le; Angela Brooks-Wilson; Linda E Kelemen; Ian Campbell; Simon A Gayther; Susan J Ramus; Aleksandra Gentry-Maharaj; Usha Menon; Shahana Ahmed; Caroline Baynes; Paul D Pharoah; Kenneth Muir; Artitaya Lophatananon; Arkom Chaiwerawattana; Surapon Wiangnon; Stuart Macgregor; Douglas F Easton; Roger R Reddel; Ellen L Goode; Georgia Chenevix-Trench
Journal:  PLoS One       Date:  2011-09-15       Impact factor: 3.240

5.  PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein.

Authors:  C G Li; J E Nyman; A W Braithwaite; M R Eccles
Journal:  Oncogene       Date:  2011-05-23       Impact factor: 9.867

6.  Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis.

Authors:  Tina Di Palma; Anna Conti; Tiziana de Cristofaro; Serena Scala; Lucio Nitsch; Mariastella Zannini
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7.  PAX Genes in Cancer; Friends or Foes?

Authors:  Caiyun G Li; Michael R Eccles
Journal:  Front Genet       Date:  2012-01-31       Impact factor: 4.599

8.  A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells.

Authors:  Tina Di Palma; Valeria Lucci; Tiziana de Cristofaro; Maria Grazia Filippone; Mariastella Zannini
Journal:  BMC Cancer       Date:  2014-04-26       Impact factor: 4.430

9.  Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

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Diether Lambrechts; Lisa Rogmann; Pascal Guénel; Attila Teoman; Roger L Milne; Joaquin J Garcia; Angela Cox; Vijayalakshmi Shridhar; Barbara Burwinkel; Frederik Marme; Rebecca Hein; Elinor J Sawyer; Christopher A Haiman; Shan Wang-Gohrke; Irene L Andrulis; Kirsten B Moysich; John L Hopper; Kunle Odunsi; Annika Lindblom; Graham G Giles; Hermann Brenner; Jacques Simard; Galina Lurie; Peter A Fasching; Michael E Carney; Paolo Radice; Lynne R Wilkens; Anthony Swerdlow; Marc T Goodman; Hiltrud Brauch; Montserrat Garcia-Closas; Peter Hillemanns; Robert Winqvist; Matthias Dürst; Peter Devilee; Ingo Runnebaum; Anna Jakubowska; Jan Lubinski; Arto Mannermaa; Ralf Butzow; Natalia V Bogdanova; Thilo Dörk; Liisa M Pelttari; Wei Zheng; Arto Leminen; Hoda Anton-Culver; Clareann H Bunker; Vessela Kristensen; Roberta B Ness; Kenneth Muir; Robert Edwards; Alfons Meindl; Florian Heitz; Keitaro Matsuo; Andreas du Bois; Anna H Wu; Philipp Harter; Soo-Hwang Teo; Ira Schwaab; Xiao-Ou Shu; William Blot; Satoyo Hosono; 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10.  Pax8 has a critical role in epithelial cell survival and proliferation.

Authors:  T Di Palma; M G Filippone; G M Pierantoni; A Fusco; S Soddu; M Zannini
Journal:  Cell Death Dis       Date:  2013-07-18       Impact factor: 8.469
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