Grace Fan1, Stephanie Hadi, Edward Chow. 1. Rapid Response Radiotherapy Program, Toronto Sunnybrook Regional Cancer Centre, University of Toronto, Canada.
Abstract
PURPOSE: The aim of this study was to explore the presence of symptom clusters in patients with advanced cancer. PATIENTS AND METHODS: Patients with metastatic cancer referred to an outpatient palliative radiation therapy clinic were asked to rate their symptom distress using the Edmonton Symptom Assessment Scale (ESAS). Baseline demographic data were obtained. To determine interrelationships between symptoms, a principal component analysis with "varimax rotation" was performed on the 9 ESAS symptoms. RESULTS: Between January 1999 and January 2002, a total of 1296 patients with metastases provided complete baseline data on the ESAS. The most common primary cancer sites were lung, breast, and prostate. Fatigue was the highest scored symptom, followed by poor sense of well-being, pain, lack of appetite, and drowsiness. The 4 most prevalent symptoms were poor sense of well-being (92.7%), fatigue (92.2%), drowsiness (79.7%), and anxiety (78.7%). Three symptom clusters were found. Cluster 1 included lack of appetite, nausea, poor sense of well-being, and pain. Cluster 2 included fatigue, drowsiness, and shortness of breath. Cluster 3 included anxiety and depression. CONCLUSION: More work needs to be done on symptom cluster research, especially in setting a consensus in methodology.
PURPOSE: The aim of this study was to explore the presence of symptom clusters in patients with advanced cancer. PATIENTS AND METHODS: Patients with metastatic cancer referred to an outpatient palliative radiation therapy clinic were asked to rate their symptom distress using the Edmonton Symptom Assessment Scale (ESAS). Baseline demographic data were obtained. To determine interrelationships between symptoms, a principal component analysis with "varimax rotation" was performed on the 9 ESAS symptoms. RESULTS: Between January 1999 and January 2002, a total of 1296 patients with metastases provided complete baseline data on the ESAS. The most common primary cancer sites were lung, breast, and prostate. Fatigue was the highest scored symptom, followed by poor sense of well-being, pain, lack of appetite, and drowsiness. The 4 most prevalent symptoms were poor sense of well-being (92.7%), fatigue (92.2%), drowsiness (79.7%), and anxiety (78.7%). Three symptom clusters were found. Cluster 1 included lack of appetite, nausea, poor sense of well-being, and pain. Cluster 2 included fatigue, drowsiness, and shortness of breath. Cluster 3 included anxiety and depression. CONCLUSION: More work needs to be done on symptom cluster research, especially in setting a consensus in methodology.
Authors: Sarah A Marshall; Christopher C Yang; Qing Ping; Mengnan Zhao; Nancy E Avis; Edward H Ip Journal: Qual Life Res Date: 2015-10-17 Impact factor: 4.147
Authors: Leigha Rowbottom; Stephanie Chan; Liying Zhang; Rachel McDonald; Elizabeth Barnes; May Tsao; Pearl Zaki; Edward Chow Journal: Support Care Cancer Date: 2017-03-24 Impact factor: 3.603
Authors: Vithusha Ganesh; Liying Zhang; Stephanie Chan; Bo Angela Wan; Leah Drost; May Tsao; Cyril Danjoux; Elizabeth Barnes; Rachel McDonald; Leigha Rowbottom; Pearl Zaki; Ronald Chow; Matthew K Hwang; Carlo DeAngelis; Nicholas Lao; Edward Chow Journal: Support Care Cancer Date: 2017-05-23 Impact factor: 3.603
Authors: Ana Mańas; Juan Pablo Ciria; María Carmen Fernández; María Luisa Gonzálvez; Virginia Morillo; María Pérez; Xavier Masramon; Vanessa López-Gómez Journal: Clin Transl Oncol Date: 2011-09 Impact factor: 3.405
Authors: Joanne M Droney; Sophy K Gretton; Hiroe Sato; Joy R Ross; Ruth Branford; Kenneth I Welsh; William Cookson; Julia Riley Journal: Br J Clin Pharmacol Date: 2013-05 Impact factor: 4.335
Authors: Esther Kim; Thierry Jahan; Bradley E Aouizerat; Marylin J Dodd; Bruce A Cooper; Steven M Paul; Claudia West; Kathryn Lee; Patrick S Swift; William Wara; Christine Miaskowski Journal: Cancer Nurs Date: 2009 Nov-Dec Impact factor: 2.592