| Literature DB >> 18632269 |
Zhili Xin1, Hongyu Zhao, Michael D Serby, Bo Liu, Mei Liu, Bruce G Szczepankiewicz, Lissa T J Nelson, Harriet T Smith, Tom S Suhar, Rich S Janis, Ning Cao, Heidi S Camp, Christine A Collins, Hing L Sham, Teresa K Surowy, Gang Liu.
Abstract
A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitors. 4-(2-Chlorophenoxy)-N-[3-(methyl carbamoyl)phenyl]piperidine-1-carboxamide 4c exhibited robust in vivo activity with dose-dependent desaturation index lowering effects.Entities:
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Year: 2008 PMID： 18632269 DOI： 10.1016/j.bmcl.2008.06.088
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823