Literature DB >> 18632190

Cyclocondensation reaction of heterocyclic carbonyl compounds. Part XIII: synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines.

Tomás Gucký1, Iveta Frysová, Jan Slouka, Marián Hajdúch, Petr Dzubák.   

Abstract

A series of the 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines have been synthesized in five steps. The cytotoxic activity of all of the newly synthesized compounds has been tested in vitro against five cancer cell lines. Several compounds demonstrated significant broad cytotoxic activity in low micromolar range, while others were selectively active against lung adenocarcinoma cell line A549.

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Year:  2008        PMID： 18632190     DOI： 10.1016/j.ejmech.2008.05.026

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

1.  Design and Synthesis of Some New Furan-Based Derivatives and Evaluation of In Vitro Cytotoxic Activity.

Authors:  Syed Nasir Abbas Bukhari; Hasan Ejaz; Mervat A Elsherif; Kashaf Junaid; Islam Zaki; Reham E Masoud
Journal:  Molecules       Date:  2022-04-18       Impact factor: 4.927

2.  The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon Cancer Cells.

Authors:  Agnieszka Gornowicz; Anna Szymanowska; Mariusz Mojzych; Krzysztof Bielawski; Anna Bielawska
Journal:  Int J Mol Sci       Date:  2020-07-23       Impact factor: 5.923

3.  Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer.

Authors:  Justyna Magdalena Hermanowicz; Anna Szymanowska; Beata Sieklucka; Robert Czarnomysy; Krystyna Pawlak; Anna Bielawska; Krzysztof Bielawski; Joanna Kalafut; Alicja Przybyszewska; Arkadiusz Surazynski; Adolfo Rivero-Muller; Mariusz Mojzych; Dariusz Pawlak
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

4.  Spectroscopic Behavior and Photophysical Parameters of 2-(Acetoxymethyl)-6-(1,2,4-triazinylaminodihydroquinazolinyl)tetrahydropyran Derivative in Different Solid Hosts.

Authors:  Mahmoud E M Sakr; Maram T H Abou Kana; Ahmed H M Elwahy; Mohamed S Abdelwahed; Samy A El-Daly; El-Zeiny M Ebeid
Journal:  J Fluoresc       Date:  2022-05-06       Impact factor: 2.525

5.  Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity.

Authors:  Islam Zaki; Amal M Y Moustafa; Botros Y Beshay; Reham E Masoud; Mohammed A I Elbastawesy; Mohammed A S Abourehab; Mohamed Y Zakaria
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

6.  Design, synthesis, cytotoxicity evaluation and docking studies of 1,2,4-triazine derivatives bearing different arylidene-hydrazinyl moieties as potential mTOR inhibitors.

Authors:  Sara Ranjbar; Najmeh Edraki; Mahsima Khoshneviszadeh; Alireza Foroumadi; Ramin Miri; Mehdi Khoshneviszadeh
Journal:  Res Pharm Sci       Date:  2018-02

Review 7.  Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives.

Authors:  Zofia Bernat; Anna Szymanowska; Mateusz Kciuk; Katarzyna Kotwica-Mojzych; Mariusz Mojzych
Journal:  Molecules       Date:  2020-08-29       Impact factor: 4.411
  7 in total

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