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Literature DB >> 1863219

Failure to obtain drug-resistant variants of influenza virus after treatment with inhibiting doses of 3-deazaadenosine and H7.

Abstract

3-Deazaadenosine and H7 specifically inhibit influenza virus replication under conditions at which they have no effect on other tested RNA viruses. This effect can be significantly potentiated by concomitant application of both compounds. Even under the most stringent conditions we failed to obtain any drug resistant variants. A possible explanation for this failure is that these compounds presumably do not act on a viral component like amantadine which was used as a control, but they interfere with cellular enzymes (factors) absolutely essential for influenza virus replication but more or less dispensable for the survival of the cell.

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Year: 1991 PMID： 1863219 DOI： 10.1007/bf01314327

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

11 in total

1. Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures.

Authors: R M Krug; M A Morgan; A J Shatkin
Journal: J Virol Date: 1976-10 Impact factor: 5.103

2. Incomplete forms of influenza virus.

Authors: P VON MAGNUS
Journal: Adv Virus Res Date: 1954 Impact factor: 9.937

3. High nucleotide substitution error frequencies in clonal pools of vesicular stomatitis virus.

Authors: D A Steinhauer; J C de la Torre; J J Holland
Journal: J Virol Date: 1989-05 Impact factor: 5.103

Review 4. Rapid evolution of RNA viruses.

Authors: D A Steinhauer; J J Holland
Journal: Annu Rev Microbiol Date: 1987 Impact factor: 15.500

5. Measurement of the mutation rates of animal viruses: influenza A virus and poliovirus type 1.

Authors: J D Parvin; A Moscona; W T Pan; J M Leider; P Palese
Journal: J Virol Date: 1986-08 Impact factor: 5.103

6. Specific inhibition of the synthesis of influenza virus late proteins and stimulation of early, M2, and NS2 protein synthesis by 3-deazaadenosine.

Authors: A A Fischer; K Müller; C Scholtissek
Journal: Virology Date: 1990-08 Impact factor: 3.616

7. Effects of the S-adenosylhomocysteine hydrolase inhibitors 3-deazaadenosine and 3-deazaaristeromycin on RNA methylation and synthesis.

Authors: P S Backlund; D Carotti; G L Cantoni
Journal: Eur J Biochem Date: 1986-10-15

8. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

Authors: H Hidaka; M Inagaki; S Kawamoto; Y Sasaki
Journal: Biochemistry Date: 1984-10-09 Impact factor: 3.162

Failure to obtain drug-resistant variants of influenza virus after treatment with inhibiting doses of 3-deazaadenosine and H7.

1. Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures.

2. Incomplete forms of influenza virus.

3. High nucleotide substitution error frequencies in clonal pools of vesicular stomatitis virus.

Review 4. Rapid evolution of RNA viruses.

5. Measurement of the mutation rates of animal viruses: influenza A virus and poliovirus type 1.

6. Specific inhibition of the synthesis of influenza virus late proteins and stimulation of early, M2, and NS2 protein synthesis by 3-deazaadenosine.

7. Effects of the S-adenosylhomocysteine hydrolase inhibitors 3-deazaadenosine and 3-deazaaristeromycin on RNA methylation and synthesis.

8. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

9. Differential phosphorylation of the nucleoprotein of influenza A viruses.

10. The molecular basis of the specific anti-influenza action of amantadine.

1. Innate immune induction and influenza protection elicited by a response-selective agonist of human C5a.

Review 2. Prevalence and control of H7 avian influenza viruses in birds and humans.