Literature DB >> 18631130

The role of the Wilms' tumour-suppressor protein WT1 in apoptosis.

Jörg Hartkamp1, Stefan G E Roberts.   

Abstract

The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult cancer.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18631130     DOI： 10.1042/BST0360629

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  12 in total

1.  Association between WT1 polymorphisms and susceptibility to breast cancer: results from a case-control study in a southwestern Chinese population.

Authors:  Xiao-Wei Qi; Xiao-Dong Zheng; Bei-Ge Zong; Qing-Qiu Chen; Fan Zhang; Xin-Hua Yang; Yi Zhang; Jun-Lan Liu; Jun Jiang
Journal:  Am J Cancer Res       Date:  2015-02-15       Impact factor: 6.166

2.  WT1 Expression in Adult Granular Cell Tumor of the Vocal Cord and Tongue.

Authors:  Adriana Handra-Luca
Journal:  Head Neck Pathol       Date:  2015-07-11

Review 3.  A role of WT1 in cell division and genomic stability.

Authors:  Jayasha Shandilya; Stefan G E Roberts
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

4.  HtrA2, taming the oncogenic activities of WT1.

Authors:  Jörg Hartkamp; Stefan G E Roberts
Journal:  Cell Cycle       Date:  2010-07-01       Impact factor: 4.534

Review 5.  The podocyte as a target: cyclosporin A in the management of the nephrotic syndrome caused by WT1 mutations.

Authors:  Constantinos J Stefanidis; Uwe Querfeld
Journal:  Eur J Pediatr       Date:  2011-02-08       Impact factor: 3.183

6.  Membranoproliferative glomerulonephritis associated with a mutation in Wilms' tumour suppressor gene 1.

Authors:  Detlef Bockenhauer; William van't Hoff; Gil Chernin; Saskia F Heeringa; Neil J Sebire
Journal:  Pediatr Nephrol       Date:  2009-02-11       Impact factor: 3.714

Review 7.  Analyzing the coordinated gene network underlying temperature-dependent sex determination in reptiles.

Authors:  Christina M Shoemaker; David Crews
Journal:  Semin Cell Dev Biol       Date:  2008-10-30       Impact factor: 7.727

Review 8.  Mechanisms of transcriptional regulation by WT1 (Wilms' tumour 1).

Authors:  Eneda Toska; Stefan G E Roberts
Journal:  Biochem J       Date:  2014-07-01       Impact factor: 3.857

9.  WT1 expression in the human fetus during development.

Authors:  R Ambu; L Vinci; C Gerosa; D Fanni; E Obinu; A Faa; V Fanos
Journal:  Eur J Histochem       Date:  2015-06-29       Impact factor: 3.188

10.  Wilms' tumor gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line.

Authors:  Rosalba Parenti; Venera Cardile; Adriana Carol Eleonora Graziano; Carmela Parenti; Assunta Venuti; Maria Paola Bertuccio; Debora Lo Furno; Gaetano Magro
Journal:  PLoS One       Date:  2014-12-04       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.