Literature DB >> 18630921

2,6-Diazaspiro[3.3]heptanes: synthesis and application in Pd-catalyzed aryl amination reactions.

Johannes Burkhard1, Erick M Carreira.   

Abstract

A concise and scalable synthesis of a 2,6-diazaspiro[3.3]heptane building block is reported. The usefulness of this structural surrogate of piperazine is shown in arene amination reactions yielding a variety of N-Boc- N'-aryl-2,6-diazaspiro[3.3]heptanes.

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Year:  2008        PMID： 18630921     DOI： 10.1021/ol801293f

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Pd-catalyzed arylation of linear and angular spirodiamine salts under aerobic conditions.

Authors:  Sean W Reilly; Nikaela W Bryan; Robert H Mach
Journal:  Tetrahedron Lett       Date:  2016-12-23       Impact factor: 2.415

2.  The Growing Importance of Chirality in 3D Chemical Space Exploration and Modern Drug Discovery Approaches for Hit-ID: Topical Innovations.

Authors:  Ilaria Proietti Silvestri; Paul J J Colbon
Journal:  ACS Med Chem Lett       Date:  2021-07-16       Impact factor: 4.632

3.  Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.

Authors:  Christopher L Cioffi; Nicoleta Dobri; Emily E Freeman; Michael P Conlon; Ping Chen; Douglas G Stafford; Daniel M C Schwarz; Kathy C Golden; Lei Zhu; Douglas B Kitchen; Keith D Barnes; Boglarka Racz; Qiong Qin; Enrique Michelotti; Charles L Cywin; William H Martin; Paul G Pearson; Graham Johnson; Konstantin Petrukhin
Journal:  J Med Chem       Date:  2014-09-11       Impact factor: 7.446

4.  Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.

Authors:  Timothy R Hodges; Jason R Abbott; Andrew J Little; Dhruba Sarkar; James M Salovich; Jennifer E Howes; Denis T Akan; Jiqing Sai; Allison L Arnold; Carrie Browning; Michael C Burns; Tammy Sobolik; Qi Sun; Yugandhar Beesetty; Jesse A Coker; Dirk Scharn; Heinz Stadtmueller; Olivia W Rossanese; Jason Phan; Alex G Waterson; Darryl B McConnell; Stephen W Fesik
Journal:  J Med Chem       Date:  2018-09-28       Impact factor: 7.446

5.  Oxetanyl peptides: novel peptidomimetic modules for medicinal chemistry.

Authors:  Martin McLaughlin; Ryo Yazaki; Thomas C Fessard; Erick M Carreira
Journal:  Org Lett       Date:  2014-07-28       Impact factor: 6.005

6.  Accelerating fragment-based library generation by coupling high-performance photoreactors with benchtop analysis.

Authors:  Quentin Lefebvre; Christophe Salomé; Thomas C Fessard
Journal:  Beilstein J Org Chem       Date:  2020-05-12       Impact factor: 2.883
  6 in total

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