Literature DB >> 18629111

Genomics and ethics: the case of cloned and/or transgenic animals.

Béatrice de Montera1.   

Abstract

The point of the present study is to illustrate and, if possible, promote the existing link between genomics and ethics, taking the example of cloned and transgenic animals. These 'new animals' raise theoretical and practical problems that concern applied ethics. We will explore more particularly an original strategy showing that it is possible, starting from philosophical questioning about the nature of identity, to use a genomic approach, based on amplification fragment length polymorphism (AFLP) and methylation-sensitive amplification polymorphism (MSAP) detection, to provide useful tools to define more rigorously what cloned animals are, by testing their genetic and epigenetic identity. We expect from the future results of this combined approach to stimulate the creativity of the philosophical and ethical reflection about the impact of biotechnology on animals, and to increase scientific involvement in such issues.

Year:  2003        PMID: 18629111      PMCID: PMC2447398          DOI: 10.1002/cfg.243

Source DB:  PubMed          Journal:  Comp Funct Genomics        ISSN: 1531-6912


  13 in total

Review 1.  [Cloning and associated physiopathology of gestation].

Authors:  P Chavatte-Palmer; Y Heyman; J P Renard
Journal:  Gynecol Obstet Fertil       Date:  2000-09

Review 2.  Transgenesis may affect farm animal welfare: a case for systematic risk assessment.

Authors:  C G Van Reenen; T H Meuwissen; H Hopster; K Oldenbroek; T H Kruip; H J Blokhuis
Journal:  J Anim Sci       Date:  2001-07       Impact factor: 3.159

3.  Notl-Msell methylation-sensitive amplied fragment length polymorhism for DNA methylation analysis of human cancers.

Authors:  F Yamamoto; M Yamamoto; J L Soto; E Kojima; E N Wang; M Perucho; T Sekiya; H Yamanaka
Journal:  Electrophoresis       Date:  2001-06       Impact factor: 3.535

4.  Aberrant methylation of donor genome in cloned bovine embryos.

Authors:  Y K Kang; D B Koo; J S Park; Y H Choi; A S Chung; K K Lee; Y M Han
Journal:  Nat Genet       Date:  2001-06       Impact factor: 38.330

5.  AFLP: a new technique for DNA fingerprinting.

Authors:  P Vos; R Hogers; M Bleeker; M Reijans; T van de Lee; M Hornes; A Frijters; J Pot; J Peleman; M Kuiper
Journal:  Nucleic Acids Res       Date:  1995-11-11       Impact factor: 16.971

Review 6.  Large offspring syndrome in cattle and sheep.

Authors:  L E Young; K D Sinclair; I Wilmut
Journal:  Rev Reprod       Date:  1998-09

7.  DNA methylation variation in cloned mice.

Authors:  J Ohgane; T Wakayama; Y Kogo; S Senda; N Hattori; S Tanaka; R Yanagimachi; K Shiota
Journal:  Genesis       Date:  2001-06       Impact factor: 2.487

8.  Patterns of cytosine methylation in an elite rice hybrid and its parental lines, detected by a methylation-sensitive amplification polymorphism technique.

Authors:  L Z Xiong; C G Xu; M A Saghai Maroof; Q Zhang
Journal:  Mol Gen Genet       Date:  1999-04

Review 9.  Nuclear transfer technologies: between successes and doubts.

Authors:  J P Renard; Qi Zhou; D LeBourhis; P Chavatte-Palmer; I Hue; Y Heyman; X Vignon
Journal:  Theriogenology       Date:  2002-01-01       Impact factor: 2.740

10.  An exploratory analysis of multiple mutation spectra.

Authors:  P D Lewis; J M Parry
Journal:  Mutat Res       Date:  2002-07-25       Impact factor: 2.433

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