| Literature DB >> 18628663 |
Ha-Na Woo1, Jae-Woong Chang, Yun-Hyung Choi, A-Ryeong Gwon, Yong-Keun Jung, Dong-Gyu Jo.
Abstract
Earlier reports found that calsenilin is a transcriptional repressor or a subunit of plasma membrane channel, and indicated that calsenilin was present in the nucleus or plasma membrane. Immunohistochemical and subcellular fractionation analysis, however, revealed that calsenilin/DREAM/KChIP3 was distributed throughout the cytoplasm of SK-N-BE2(C), Jurkat, and HeLa cells. In addition, the expression of calsenilin suppressed the ATP-induced increase in intracellular Ca2+ concentrations. By increase in intracellular calcium concentration, calsenilin was translocated into the nucleus.Entities:
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Year: 2008 PMID： 18628663 DOI： 10.1097/WNR.0b013e3283089209
Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837