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Literature DB >> 18626943

Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell development.

Ross A Poché¹, Yasuhide Furuta, Marie-Christine Chaboissier, Andreas Schedl, Richard R Behringer.

Abstract

It is widely accepted that the process of retinal cell fate determination is under tight transcriptional control mediated by a combinatorial code of transcription factors. However, the exact repertoire of factors necessary for the genesis of each retinal cell type remains to be fully defined. Here we show that the HMG-box transcription factor, Sox9, is expressed in multipotent mouse retinal progenitor cells throughout retinogenesis. We also find that Sox9 is downregulated in differentiating neuronal populations, yet expression in Müller glial cells persists into adulthood. Furthermore, by employing a conditional knockout approach, we show that Sox9 is essential for the differentiation and/or survival of postnatal Müller glial cells. Copyright 2008 Wiley-Liss, Inc.

Entities: CellLine Chemical Disease Gene Species

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Year: 2008 PMID： 18626943 PMCID： PMC4412477 DOI： 10.1002/cne.21746

Source DB: PubMed Journal: J Comp Neurol ISSN： 0021-9967 Impact factor: 3.215

68 in total

1. Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study.

Authors: Claudia Gargini; Eva Terzibasi; Francesca Mazzoni; Enrica Strettoi
Journal: J Comp Neurol Date: 2007-01-10 Impact factor: 3.215

Review 2. Recent innovations in tissue-specific gene modifications in the mouse.

Authors: Yasuhide Furuta; Richard R Behringer
Journal: Birth Defects Res C Embryo Today Date: 2005-03

3. Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property.

Authors: Ashutosh P Jadhav; Seo-Hee Cho; Constance L Cepko
Journal: Proc Natl Acad Sci U S A Date: 2006-12-05 Impact factor: 11.205

4. Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.

Authors: Haruhiko Akiyama; Jung-Eun Kim; Kazuhisa Nakashima; Gener Balmes; Naomi Iwai; Jian Min Deng; Zhaoping Zhang; James F Martin; Richard R Behringer; Takashi Nakamura; Benoit de Crombrugghe
Journal: Proc Natl Acad Sci U S A Date: 2005-10-03 Impact factor: 11.205

5. Cell differentiation in the retina of the mouse.

Authors: R W Young
Journal: Anat Rec Date: 1985-06

6. Distributions of PAX6 and PAX7 proteins suggest their involvement in both early and late phases of chick brain development.

Authors: A Kawakami; M Kimura-Kawakami; T Nomura; H Fujisawa
Journal: Mech Dev Date: 1997-08 Impact factor: 1.882

7. A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination.

Authors: Stephan Gasca; Joaquin Canizares; Pascal De Santa Barbara; Catherine Mejean; Francis Poulat; Philippe Berta; Brigitte Boizet-Bonhoure
Journal: Proc Natl Acad Sci U S A Date: 2002-08-08 Impact factor: 11.205

8. Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina.

Authors: Orly Yaron; Chen Farhy; Till Marquardt; Meredithe Applebury; Ruth Ashery-Padan
Journal: Development Date: 2006-03-01 Impact factor: 6.868

9. Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina.

Authors: M Hojo; T Ohtsuka; N Hashimoto; G Gradwohl; F Guillemot; R Kageyama
Journal: Development Date: 2000-06 Impact factor: 6.868

10. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch.

Authors: C P Austin; D E Feldman; J A Ida; C L Cepko
Journal: Development Date: 1995-11 Impact factor: 6.868

79 in total

1. SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium.

Authors: Tomohiro Masuda; Noriko Esumi
Journal: J Biol Chem Date: 2010-06-08 Impact factor: 5.157

9. Characterization of multiple bistratified retinal ganglion cells in a purkinje cell protein 2-Cre transgenic mouse line.

Authors: Elena Ivanova; Patrick Lee; Zhuo-Hua Pan
Journal: J Comp Neurol Date: 2013-06-15 Impact factor: 3.215

Review 10. Intrinsic control of mammalian retinogenesis.

Authors: Mengqing Xiang
Journal: Cell Mol Life Sci Date: 2012-10-12 Impact factor: 9.261

Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell development.

1. Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study.

Review 2. Recent innovations in tissue-specific gene modifications in the mouse.

3. Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property.

4. Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.

5. Cell differentiation in the retina of the mouse.

6. Distributions of PAX6 and PAX7 proteins suggest their involvement in both early and late phases of chick brain development.

7. A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination.

8. Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina.

9. Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina.

10. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch.

1. SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium.

2. Muller glia, vision-guided ocular growth, retinal stem cells, and a little serendipity: the Cogan lecture.

3. Comparative study of Pax2 expression in glial cells in the retina and optic nerve of birds and mammals.

Review 4. Development of the retina and optic pathway.

5. SOX9 induces and maintains neural stem cells.

6. Stimulation of neural regeneration in the mouse retina.

7. Tracing the stemness of porcine skin-derived progenitors (pSKP) back to specific marker gene expression.

Review 8. Pituitary gland development and disease: from stem cell to hormone production.

9. Characterization of multiple bistratified retinal ganglion cells in a purkinje cell protein 2-Cre transgenic mouse line.

Review 10. Intrinsic control of mammalian retinogenesis.