Literature DB >> 18626726

Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7.

Tomonori Nakamura, Naoko Kodama, Takuya Kumamoto, Yoshihiro Higuchi, Chaiyo Chaichantipyuth, Koichi Ueno, Tsutomu Ishikawa, Shingo Yano.   

Abstract

In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7. From this screening, the extracts of root bark of Clausena guillauminii, C. lunulata, and C. excavata (Rutaceae) were found as the extracts which showed potent inhibitory effect on the iNOS protein expression in concentration-dependent manner. Furthermore, hydrophobic active components may exist in C. guillauminii.

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Year:  2008        PMID： 18626726     DOI： 10.1007/s11418-008-0276-6

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  8 in total

1.  Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.

Authors:  Arunrat Sunthitikawinsakul; Ngampong Kongkathip; Boonsong Kongkathip; Sida Phonnakhu; John W Daly; Thomas F Spande; Yuth Nimit; Sasarose Rochanaruangrai
Journal:  Planta Med       Date:  2003-02       Impact factor: 3.352

Review 2.  Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator?

Authors:  H Kolb; V Kolb-Bachofen
Journal:  Immunol Today       Date:  1998-12

3.  Nitric oxide and peroxynitrite released by ultraviolet B-irradiated human endothelial cells are possibly involved in skin erythema and inflammation.

Authors:  G Deliconstantinos; V Villiotou; J C Stavrides
Journal:  Exp Physiol       Date:  1996-11       Impact factor: 2.969

Review 4.  Nitric oxide and inflammatory arthritides.

Authors:  N Miyasaka; Y Hirata
Journal:  Life Sci       Date:  1997       Impact factor: 5.037

Review 5.  The role of iNOS in chronic inflammatory processes in vivo: is it damage-promoting, protective, or active at all?

Authors:  Christoph V Suschek; Oliver Schnorr; Victoria Kolb-Bachofen
Journal:  Curr Mol Med       Date:  2004-11       Impact factor: 2.222

6.  A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression.

Authors:  Akihiro Hosokawa; Megumi Sumino; Tomonori Nakamura; Shingo Yano; Toshikazu Sekine; Nijsiri Ruangrungsi; Kazuko Watanabe; Fumio Ikegami
Journal:  Chem Pharm Bull (Tokyo)       Date:  2004-10       Impact factor: 1.645

7.  Alterations of nitric oxide synthase and xanthine oxidase activities of human keratinocytes by ultraviolet B radiation. Potential role for peroxynitrite in skin inflammation.

Authors:  G Deliconstantinos; V Villiotou; J C Stavrides
Journal:  Biochem Pharmacol       Date:  1996-06-28       Impact factor: 5.858

8.  A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes.

Authors:  D Bruch-Gerharz; K Fehsel; C Suschek; G Michel; T Ruzicka; V Kolb-Bachofen
Journal:  J Exp Med       Date:  1996-11-01       Impact factor: 14.307
  8 in total
  1 in total

1.  Simultaneous determination of nine analytes in Clausena harmandiana Pierre. by new developed high-performance liquid chromatography method and the influence of locations in Thailand on level of nordentatin and dentatin.

Authors:  Jinda Wangboonskul; Amolnat Tunsirikongkon; Watikan Sasithornwetchakun
Journal:  Pharmacogn Mag       Date:  2015 Jan-Mar       Impact factor: 1.085
  1 in total

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