| Literature DB >> 18626493 |
Abstract
The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.Entities:
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Year: 2008 PMID： 18626493 DOI： 10.1038/ki.2008.260
Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612